2-[(4-chloro-2-nitrophenyl)azo]-N-(2-chlorophenyl)-3-oxobutyramide

Nanomaterial dustiness

Administrative data

Endpoint:

nanomaterial dustiness

Type of information:

experimental study

Adequacy of study:

key study

Study period:

04 Nov 2020 - 11 Nov 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Remarks:

According to DIN EN 17199-3

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: DIN EN 17199-3

Version / remarks:

DIN EN 17199-3:2019-12 “Workplace exposure - Measurement of dustiness of bulk materials that contain or release respirable NOAA or other respirable particles - Part 3: Continuous drop method

Deviations:

yes

Remarks:

1 measurement performed

GLP compliance:

no

Type of method:

continuous drop

Sampling:

The test material was used without further treatment (e.g. drying). The relative humidity of the test atmosphere was 48%. 182.2 g (630.4 cm³) test material was used for the measurement, at a dosing rate of 18.2 g/min. 1 measurement was performed for background and sample, with a measurement duration of 3 and 10 minutes, respecitvely.

Test material

Test material information

Constituent 1

Reference substance name:

2-[(4-chloro-2-nitrophenyl)azo]-N-(2-chlorophenyl)-3-oxobutyramide

EC Number:

229-355-1

EC Name:

2-[(4-chloro-2-nitrophenyl)azo]-N-(2-chlorophenyl)-3-oxobutyramide

Cas Number:

6486-23-3

Molecular formula:

C16H12Cl2N4O4

IUPAC Name:

2-[(4-chloro-2-nitrophenyl)diazenyl]-N-(2-chlorophenyl)-3-oxobutanamide

Test material form:

solid: nanoform, no surface treatment

Results and discussion

Dustiness index

Dustiness index 1

Key result

Mean:

46 281.3 other: particles/mg

Remarks on result:

other: dustiness index as number of airborne particles per mg in the nanoscale (10 nm - 100 nm)

Dustiness index 2

Mean:

15 910.3 other: particles/cm³

Remarks on result:

other: number of airborne nanoparticles per cm³, size range 10-100 nm

Any other information on results incl. tables

The cleaned, almost particle-free air had a total particle count of 5 particles/cm³ in the range of 10 nm – 417 nm, whereby the nanoscale fraction (10 - 100 nm) contained 3 particles/cm³.

Summary SMPS result:

Range [nm]	Mean [nm]	Concentration [ particles /cm³]	I(CD) [particles/mg]	E(CD) [1/mg·s]
10 -100	47.0	15910.3	46281.3	77.1
100 - 417	159.9	2512.2	7307.4	12.2
10 - 417	62.4	18422.4	53588.7	89.3

Summary OPS result:

Range [µm]	Mean [µm]	Concentration [ particles /cm³]	I(CD) [particles/mg]	E(CD) [1/mg·s]
0.3 - 10	5.6	337.9	982.8	1.6

ICD: dustiness index as number of airborne particles per mg

ECD: emission rate as number of particles per mg per second

mean: average particle diameter in nm

N: number of airborne particles

Applicant's summary and conclusion

Executive summary:

The dusting behaviour of the test material was investigated using DIN EN 17199-3:2019-12 "workplace exposure - measurement of dustiness of bulk materials that contain or release respirable nano objects and their aggregates and agglomerates or other respirable particles- Part 3: Continuous drop method".

The dust released by the falling test material was measured by a scanning mobility particle sizer (SMPS, 10 - 417 nm) and an optical particle sizer (3 - 10 µm). The counterflow was provided by clean, almost particle-free air.

The SMPS counted 15910.3 particles in the nanoscale (10 - 100 nm) per cm³, corresponding to a dustiness index of 46281.3 particles in the nanoscale (10 - 100 nm) per mg. The particle number in the whole SMPS size range (10-417 nm) was 18422.4 per cm³, corresponding to a dustiness index of 53588.7 particles/mg (size 10 - 417 nm).

The mean size of the nanoparticles was 47.0 nm, the mean size of particles in the range 10 - 417 nm was 62.4.

The OPS (0.3 - 10 µm) counted 337.9 particles per cm³ corresponding to a dustiness index of 982.8 particles per mg. The mean size of the particles was 1.6 µm.