Registration Dossier
Registration Dossier
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EC number: 800-428-5 | CAS number: 1256387-74-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- tert-butyl (1R,3S,4S)-3-(6-bromo-1H-1,3-benzodiazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate
- EC Number:
- 800-428-5
- Cas Number:
- 1256387-74-2
- Molecular formula:
- C18H22BrN3O2
- IUPAC Name:
- tert-butyl (1R,3S,4S)-3-(6-bromo-1H-1,3-benzodiazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- "In conclusion, the LD50 of the test item GS-459990 is higher than 300 mg/kg and lower than 2000mg/kg body weight by oral route in the rat.
According to the criteria for classification, packaging and labelling of dangerous substances and preparations in accordance with the E.E.C. Directives 67/548, 2001/59 and 99/45, the test item GS-459990 must be classified R22 “Harmful if swallowed”. The item must be characterised by the symbol “Xn” and the warning label “Harmful”.
In accordance with the Regulation EC No. 1272/2008, the test item must be classified in category 4. The signal word “Warning” and hazard statement H302 “Harmful if swallowed” are required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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