Registration Dossier
Registration Dossier
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EC number: 203-013-1 | CAS number: 102-20-5
Endpoint summary
Administrative data
Description of key information
Biodegradation in water:
28-days Manometric respirometry test following the OECD guideline 301F was conducted to determine the ready biodegradability of the test chemical. The study was performed at a temperature of 20± 1°C. Mixture of domestic waste water, surface soil and soil samples was used as a test inoculum for the study. OECD mineral medium was used for the study. The test system included control, test item and reference item. The concentration of test and reference item ( Sodium Benzoate) chosen for both the study was 100 mg/L, while that of inoculum was 10 ml/l. ThOD (Theoretical oxygen demand) of test and reference item was determined by calculation. % Degradation was calculated using the values of BOD and ThOD for test item and reference item. The % degradation of procedure control (reference substance) was also calculated using BOD & ThOD and was determined to be 227.4%. The DO depletion (mg O2/l) in control on 28th day is 19.1 mg O2/l which fulfills the control validity criteria (i.e., The DO depletion of the inoculum blank is normally 20-30 mg O2/l and should not be greater than 60 mg/l in 28 days). Degradation of Sodium acetate exceeds 168.29% after 7 days and 212.76 % after 14 days. The activity of the inoculum is thus verified and the test is considered as valid. The BOD28 value of test chemical was observed to be 0.814 mgO2/mg. ThOD was calculated as 2.53 mgO2/mg. Accordingly, the % degradation of the test chemical after 28 days of incubation at 20 ± 1°C according to manometric respirometry test was determined to be 32.17%. Based on the results, the test chemical was considered to be inherently biodegradable at 20 ± 1°C over a period of 28 days.
Biodegradation in water: simulation testing on ultimate degradation in surface in water-
Estimation Programs Interface prediction model was run to predict the half-life in water for the test chemical. If released in to the environment, 15.7% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical was not persistent in water and the exposure risk to aquatic animals is moderate to low.
Biodegradation in sediment: simulation tests - Estimation Programs Interface prediction model was run to predict the half-life in sediment for the test chemical. The half-life period of test chemical in sediment was estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment was less than 8% (i.e, reported as 7.47%), indicates that test chemical is not persistent in sediment.
Biodegradation in soil:
The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database. If released into the environment, 76.1% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil was estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water:
28-days Manometric respirometry test following the OECD guideline 301F was conducted to determine the ready biodegradability of the test chemical. The study was performed at a temperature of 20± 1°C. Mixture of domestic waste water, surface soil and soil samples was used as a test inoculum for the study. OECD mineral medium was used for the study. The test system included control, test item and reference item. The concentration of test and reference item ( Sodium Benzoate) chosen for both the study was 100 mg/L, while that of inoculum was 10 ml/l. ThOD (Theoretical oxygen demand) of test and reference item was determined by calculation. % Degradation was calculated using the values of BOD and ThOD for test item and reference item. The % degradation of procedure control (reference substance) was also calculated using BOD & ThOD and was determined to be 227.4%. The DO depletion (mg O2/l) in control on 28th day is 19.1 mg O2/l which fulfills the control validity criteria (i.e., The DO depletion of the inoculum blank is normally 20-30 mg O2/l and should not be greater than 60 mg/l in 28 days). Degradation of Sodium acetate exceeds 168.29% after 7 days and 212.76 % after 14 days. The activity of the inoculum is thus verified and the test is considered as valid. The BOD28 value of test chemical was observed to be 0.814 mgO2/mg. ThOD was calculated as 2.53 mgO2/mg. Accordingly, the % degradation of the test chemical after 28 days of incubation at 20 ± 1°C according to manometric respirometry test was determined to be 32.17%. Based on the results, the test chemical was considered to be inherently biodegradable at 20 ± 1°C over a period of 28 days.
Biodegradation in water: simulation testing on ultimate degradation in surface in water-
Estimation Programs Interface prediction model was run to predict the half-life in water for the test chemical. If released in to the environment, 15.7% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical was not persistent in water and the exposure risk to aquatic animals is moderate to low.
Biodegradation in sediment: simulation tests - Estimation Programs Interface prediction model was run to predict the half-life in sediment for the test chemical. The half-life period of test chemical in sediment was estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment was less than 8% (i.e, reported as 7.47%), indicates that test chemical is not persistent in sediment.
Biodegradation in soil:
The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database. If released into the environment, 76.1% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil was estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
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