Registration Dossier
Registration Dossier
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EC number: 202-299-5 | CAS number: 94-05-3
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: case of occupational exposure
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Systemic Contact Allergy from Occupational Contact with Ethyl Ethoxymethylene Cyanoacetate
- Year:
- 1 992
- Bibliographic source:
- Contact Dermatitis, Vol.27, No. 1, pages 58-59, 6 references (TOXNET Toxicology Data Network)
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- No method following. This is a reported case of occupational exposure and sensitisation.
- GLP compliance:
- no
Test material
- Reference substance name:
- Ethyl 2-cyano-3-ethoxyacrylate
- EC Number:
- 202-299-5
- EC Name:
- Ethyl 2-cyano-3-ethoxyacrylate
- Cas Number:
- 94-05-3
- Molecular formula:
- C8H11NO3
- IUPAC Name:
- ethyl 2-cyano-3-ethoxyacrylate
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 1
- Sex: man
- Other: worker on a pharmaceutical production line - Route of administration:
- dermal
Results and discussion
- Results of examinations:
- The worker developed pruritic erythematous paches on his wrist after an initial exposure to the Ethyl Ethoxymethylene Cyanoacetate (EEMC). Subsequent exposure to vapor resulted in localized eczematous patches, generalized erythematous maculopapules, vesicles and erythema multiforme like eruptions on the face, neck and extremities.
Upon hospital admission, digital numbness, cold, clammy fingers, and hand tremor were seen. The patient was treated with systemic corticosteroids and antihistamines. A positive reaction to EEMC on patch tests was seen, and the examination of blood and urine specimens using high performance liquid chromatography demonstrated the presence of EEMC.
Virtually all of the symptoms resolved when the patient was transferred from the EEMC production line.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
