Registration Dossier
Registration Dossier
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EC number: 216-676-7 | CAS number: 1638-86-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Diethylphenylphosphonite is a good substrate for the pig liver microsomal FAD-containing monooxygenase in an in vitro test but, due to its rapid nonenzymatic hydrolysis and/or oxidation, only a small amount could be metabolised by the enzyme.
Key value for chemical safety assessment
Additional information
The test substance (Diethylphenylphosphonite) and similar substances have been examined as possible substrates for pig liver microsomal FAD-containing monooxygenase in an vitro test. From the test results it can be concluded that the phosphonite is an excellent substrate for the enzyme but that its rapid nonenzymatic hydrolysis and/or oxidation prohibit calculation of stoichiometric and kinetic values. The major metabolite was Diethylphenylphosphine oxide.
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