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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Danish (Q)SAR Database
Title:
Danish (Q)SAR Study for 2494-88-4
Year:
2012
Bibliographic source:
Commercial

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Ames mutagenicity. Multicase model.
GLP compliance:
no
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[(3-aminophenyl)sulphonyl] hydrogensulphate
EC Number:
219-668-1
EC Name:
2-[(3-aminophenyl)sulphonyl] hydrogensulphate
Cas Number:
2494-88-4
Molecular formula:
C8H11NO6S2
IUPAC Name:
[2-(3-aminobenzenesulfonyl)ethoxy]sulfonic acid

Results and discussion

Test results
Species / strain:
other: Salmonella
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
no cytotoxicity
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
AMES test of the substance to Salmonella is negative.