Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication

Data source

Reference
Reference Type:
publication
Title:
Monographs on Fragrance Raw Materials: l-Carvone.
Author:
D. L. J. Opdyke
Year:
1973
Bibliographic source:
Food and Cosmetics Toxicology, Volume 11, Issue 6, December 1973, Pages 1057-1058.

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
In vivo Metabolism study of l-carvone in rabbit
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
L-p-mentha-1(6),8-dien-2-one
EC Number:
229-352-5
EC Name:
L-p-mentha-1(6),8-dien-2-one
Cas Number:
6485-40-1
Molecular formula:
C10H14O
IUPAC Name:
(5R)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one
Test material form:
liquid
Details on test material:
- IUPAC Name: L-p-mentha-1(6),8-dien-2-one
- Common Name: L-carvone
- InChI:1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9H,1,5-6H2,2-3H3/t9-/m1/s1
- Smiles:C1[C@@H](CC=C (C1=O)C)C(C)=C
- Molecular formula : C10H14O
- Molecular weight : 150.2196 g/mol
- Substance type: organic
- Physical state: Colorless liquid
Specific details on test material used for the study:
- IUPAC Name: L-p-mentha-1(6),8-dien-2-one
- Common Name: L-carvone
- InChI:1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9H,1,5-6H2,2-3H3/t9-/m1/s1
- Smiles:C1[C@@H](CC=C (C1=O)C)C(C)=C
- Molecular formula : C10H14O
- Molecular weight : 150.2196 g/mol
- Substance type: organic
- Physical state: Colorless liquid
Radiolabelling:
not specified

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
not specified
Vehicle:
not specified
No. of animals per sex per dose / concentration:
not specified
Control animals:
not specified
Positive control reference chemical:
not specified
Details on study design:
not specified
Details on dosing and sampling:
not specified
Statistics:
not specified

Results and discussion

Preliminary studies:
not specified
Main ADME results
Type:
metabolism
Results:
Carvone was metabolized to 1,5-dimethyl-l,5-hexadien-l,6-dicarboxylic acid and a carbinol in which one ethylene linkage was saturated and the keto group was reduced.

Toxicokinetic / pharmacokinetic studies

Details on absorption:
not specified
Details on distribution in tissues:
not specified
Details on excretion:
not specified

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
1,5-dimethyl-l,5-hexadien-l,6-dicarboxylic acid

Applicant's summary and conclusion

Conclusions:
Low bio-accumulation potential based on study results
Executive summary:

Available data pertaining to the in-vivo Metabolism of the chemical l-Carvone suggests metabolism of l-Carvone to 1,5 -dimethyl-l,5 -hexadien-l,6 - dicarboxylic acid and a carbinol in which one ethylene linkage was saturated and the keto group was reduced.Thus, there is no evidence that they or their metabolites would accumulate in tissues and cause a concern for consumer safety. Also, the use in fragrances in the USA, amounts to less than 2000 lb/yr. Hence it is concluded that l-Carvone is likely to exhibit low bio-accumulation potential based on study results and use.