Registration Dossier
Registration Dossier
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EC number: 617-344-8 | CAS number: 82543-09-7
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Study period:
- 2002
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Estimation based on hydrolysis rate constants of structurally similar substance
- GLP compliance:
- no
Test material
- Reference substance name:
- 7 beta-Hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5-androsten-17-one
- EC Number:
- 617-344-8
- Cas Number:
- 82543-09-7
- Molecular formula:
- C25 H36 O4
- IUPAC Name:
- 7 beta-Hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5-androsten-17-one
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- no
Results and discussion
- Transformation products:
- not measured
Applicant's summary and conclusion
- Executive summary:
On the basis of the structural similarity of the test substance ZK 90506 with ZK 90504 hydrolytic stability is to be expected at pH 4, 7 and 9. The rate of hydrolysis of ZK 90504 was determined at pH 4, 7 and 9 (see Schering report No. A11338). The half-lives of ZK 90504 at 25 °C are: pH 4: stable, pH 7: stable, pH 9: 2.7 a (95 % confidence limit: 2.2 to 3.5 a).
According to the criterion in EC guideline C.7 (half-life > 1 year at 25 °C) ZK 90504 is to be considered stable at pH 4, 7 and 9, 25 °C. Similar rates of hydrolysis are to be expected for the test substance ZK 90506.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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