Registration Dossier
Registration Dossier
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EC number: 248-326-4 | CAS number: 27213-90-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 100 mg/kg bw/day
- Species:
- rat
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
The lowest NOAEL available for the selected study is 100 mg/kg bw/day based on clinical findings in males of P generation.
Justification for selection of Effect on fertility via oral route:
The selected study is the only experimental study available.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 10 mg/kg bw/day
- Species:
- rat
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
The lowest NOAEL available for the selected study is 10 mg/kg bw/day based on maternal toxicity.
Justification for selection of Effect on developmental toxicity: via oral route:
The selected study is the only experimental study available.
Toxicity to reproduction: other studies
Additional information
The findings of the reproductive/developmental toxicity studies reported effects, mainly in presence of maternal toxicity, for which a hazard classification is not foreseen.
Justification for classification or non-classification
The substance is not classified for reproductive toxicity according to Regulation 1272/2008/EC.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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