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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Methyl pentynol is a structural analogon to the to be registered substance. Justification for read across is perfectly provided in the document "Screening-Level Hazard Characterization and Prioritization Document on ALPHA HYDROXY ALKYNES CLUSTER - 4 Chemicals" prepared by EPA in 2009. This document is attached at this endpoint of this dossier.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Section 1500.42 - Hazardous Substances and Articles, Administration and Enforcement Regulations, Federal Register, Vol . 38, No. 187, P. 27019, 27 September 1973
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Methylpentynol
EC Number:
201-055-5
EC Name:
Methylpentynol
Cas Number:
77-75-8
IUPAC Name:
3-methylpent-1-yn-3-ol
Constituent 2
Reference substance name:
3-Methyl-1-pentyn-3-ol
IUPAC Name:
3-Methyl-1-pentyn-3-ol
Test material form:
liquid: viscous

Test animals / tissue source

Species:
rabbit
Strain:
other: albino

Test system

Vehicle:
unchanged (no vehicle)
Controls:
yes, concurrent no treatment
Amount / concentration applied:
0.1 ml
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
6 animals

Results and discussion

Any other information on results incl. tables

Hours After Application Days After Application
1 24 72 5 7
Rabbit Number Cornea Iris Conjunctivae Cornea Iris Conjunctivae Cornea Iris Conjunctivae Cornea Iris Conjunctivae Cornea Iris Conjunctivae Cornea Iris Conjunctivae
1 40 10 20 40 10 20 40 10 20 40 10 20 40 10 20 40 10 16
2 40 10 20 40 10 20 40 10 16 40 10 16 40 10 14 40 10 12
3 40 10 20 40 10 20 40 10 20 40 10 20 40 10 20 40 10 18
4 40 10 20 40 10 20 40 10 12 40 10 12 40 10 10 40 10 10
5 40 10 20 40 10 20 40 10 20 40 10 20 40 10 20 40 10 20
6 40 10 20 40 10 20 40 10 18 40 10 16 40 10 16 40 10 16

Applicant's summary and conclusion

Interpretation of results:
other: primary ocular irritant
Remarks:
Criteria used for interpretation of results: other: Section 1500.42 (b) (1) (2) P. 27019 - "Illustrated Guide for Grading Eye Irritation By Hazardous Substances"
Conclusions:
The subject material is a primary ocular irritant within the definition of the Act-Reference:
Section 1500.42 (b) (1) (2) P. 27019 and requires cautionary labeling with respect to that section.
Executive summary:

The subject material is a primary ocular irritant within the definition of the Act-Reference:

Section 1500.42 (b) (1) (2) P. 27019 and requires cautionary labeling with respect to that section.