Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

On the basis of the result, interpreted according to OECD 471:1997 and ISO 10993 -3, the test item "1,3 DYPHENYLPROPANE-1,3 -DIONE" tested as recommended by Standards, proved to be NOT MUTAGENIC for all the test strains, either in the presence or absence of metabolic activation.

According to OECD 476:1997 “In Vitro Mammalian Cell Gene Mutation Test”, under the test conditions applied, the test substance 1,3-Dyphenylpropane-1,3-Dione batch n°131211-E is considered to induce gene mutations in the cultured mammalian cells used.

According to OECD 487:2010 In vitro mammalian micronucleus test. Under the test condition 24 hours –S9 the test substance induced chromosome breakage loss at a concentration of 7,67 μg/ml, in cultured mammalian cells.

Endpoint Conclusion: Adverse effect observed (positive)

Justification for classification or non-classification