Registration Dossier
Registration Dossier
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EC number: 253-506-0 | CAS number: 37439-34-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 2010
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: SkinEthic Reconstituted Human Corneal Model (HCE, Skinethic Laboratories Nice, France)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Sodium 3,5,6-trichloropyridin-2-olate
- EC Number:
- 253-506-0
- EC Name:
- Sodium 3,5,6-trichloropyridin-2-olate
- Cas Number:
- 37439-34-2
- Molecular formula:
- C5HCl3NONa
- IUPAC Name:
- sodium 3,5,6-trichloropyridin-2-olate
- Details on test material:
- - Name of test material (as cited in study report): 2(1H)-pyridinone, 3,5,6-trichloro-, sodium salt
- Physical state: white powder
- Lot/batch No.: 2010040701
- Storage condition of test material: app. 4°C in the dark
Constituent 1
Test animals / tissue source
- Species:
- other: SKinEthic HCE tissue
- Strain:
- other: SKinEthic HCE tissue
Test system
- Vehicle:
- other: MTT solution
- Controls:
- no
- Duration of treatment / exposure:
- 10 minutes
- Observation period (in vivo):
- The tissue was observed right after 10 minutes exposure.
- Number of animals or in vitro replicates:
- 0
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 10 minutes
- Reversibility:
- not specified
Any other information on results incl. tables
The relative mean viability of the test material treated tissues after 10 minutes exposure was 106.9%. It was considered unnecessary to proceed with tissue histopathology.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: mean viability of test material treated tissue was 106.9%
- Conclusions:
- According to the protocol followed the test material was considered to be a non-irritant.
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