Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 202-761-6 | CAS number: 99-51-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative databases
- Title:
- Revised Robust Study Summaries and Test Plan for 1,2-dimethyl-4-nitrobenzene
- Author:
- U.S. Environmental Protection Agency
- Year:
- 2 009
- Bibliographic source:
- High Production Volume Challenge Program; Fisher, J., 1975, Toxicity data for o-xylene,4-nitro. Report No. A75-138, American Cyanamid Company, Agricultural Division, Princeton, NJ.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is taken from HPV challenge Program.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-nitro-o-xylene
- EC Number:
- 202-761-6
- EC Name:
- 4-nitro-o-xylene
- Cas Number:
- 99-51-4
- Molecular formula:
- C8H9NO2
- IUPAC Name:
- 4-nitro-o-xylene
- Details on test material:
- Substance Name : 4-nitro-o-xylene
Molecular Formula : C8H9NO2
Physical state : Liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Results and discussion
In vivo
Results
- Irritation parameter:
- other:
- Remarks on result:
- other: Not irritating
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The database indicated that 4-nitro-o-xylene is not irritating to eyes of rabbits.
- Executive summary:
The database indicated that 4-nitro-o-xylene is not irritating to eyes of rabbits.
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