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EC number: 605-539-0 | CAS number: 169115-74-6
Vapour pressure
Administrative data
Link to relevant study record(s)
Description of key information
The vapour pressures of carbamic acid, (2-hydroxypropyl)-, compd. with 1-amino-2-propanol (1:1) were determined as 6 hPa at 20 °C, 53 hPa at 50 °C and 85 hPa at 55 °C.
The vapour pressure of 1 -amino-2 -propanol was predicted using the QSAR calculation of the Estimation Programm Interface EPI-Suite v4.1. The experimental melting point of 25 °C and boiling point of 160 °C (at 1013 hPa) were taken into account for estimation. Using the modified Grain method, the vapour pressure was estimated to be 91.4 Pa at 25°C.
The vapour pressure of ethylene glycol was predicted using the QSAR calculation of the Estimation Programm Interface EPI-Suite v4.1. The experimental boiling point of 197.3 °C (at 1013 hPa) was taken into account for estimation. Using the modified Grain method, the vapour pressure was estimated to be 7.24 Pa at 25 °C.
The vapour pressure of 2 -hydroxypropylcarbamic acid was predicted using the QSAR calculation of the Estimation Programm Interface EPI-Suite v4.1. The calculated melting point of 57.52 °C and boiling point of 257.06 °C were taken into account for estimation. Using the modified Grain method, the vapour pressure was estimated to be 0.136 Pa at 25 °C.
The predicted value can be considered reliable yielding a useful result for further assessment.
Key value for chemical safety assessment
- Vapour pressure:
- 6 hPa
- at the temperature of:
- 20 °C
Additional information
Additional information for measured data
The manufacturing process of carbamic acid, (2-hydroxypropyl)-, compound with 1-amino-2-propanol (1:1) runs solvent-based in ethylene glycol and the compound has to be continuously dissolved in about 50% ethylene glycol to ensure stability. This is the only form how the active compound carbamic acid, (2-hydroxypropyl)-, compound with 1-amino-2-propanol (1:1) can be handled and this is also the only marketed form. Because of this instability toxicological investigations cannot be performed with the ‘active ingredient’ but have to be performed with the solution in ethylene glycol. The trade name of the solubilized product is Zusatzmittel 19IF00 A.
Additional information for evaluation fo measured data and QSAR
The substance contains about 50% solvent (ethyleneglycol) and about 50% of active ingredient. It was assumed that the measured vapour pressure is mainly triggered by the solvent. However, QSAR estimations indicate that one of the substance components (1 -amino-2 -propanol) has the highest vapour pressure which is close to the measured value. Therefore, the measured vapour pressure can be assumed to be true for the active ingredient.
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