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EC number: - | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 March 2011 to 08 March 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to EU & OECD test guidance in compliance with GLP and reported with a valid GLP certificate.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Details on test material:
- Name: Reactive Blue F08-0170
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- < -2.04
- Remarks on result:
- other: Temp & pH not detailed in report
- Details on results:
- Details in table form: see any other information
Any other information on results incl. tables
Partition coefficients measured for Reactive Blue F08-0170 (Component 1)
Ratio of solvents (n-octanol : water) |
Partition coefficient |
Log Pow |
|
Pow |
Mean |
||
1:1 |
<0.0100 |
<0.0102 |
<-1.99 |
<0.0106 |
|||
<0.0100 |
|||
2:1 |
<0.0115 |
<0.0128 |
<-1.89 |
<0.0179* |
|||
<0.0141 |
|||
1:2 |
<0.0058 |
<0.0058 |
<-2.24 |
<0.0060 |
|||
<0.0056 |
|||
Mean all±95% confidence interval |
|
<0.0096±0.0088 |
<-2.04±0.436 |
SD |
|
0.0035 |
0.176 |
* chromatographic error, did not use for the calculations
Partition coefficients measured for Reactive Blue F08-170 (Component 2)
Ratio of solvents (n-octanol : water) |
Partition coefficient |
Log Pow |
|
Pow |
Mean |
||
1:1 |
<0.0079 |
<0.0080 |
<-2.10 |
<0.0082 |
|||
<0.0079 |
|||
2:1 |
<0.0105 |
<0.0112 |
<-1.95 |
<0.0120 |
|||
<0.0110 |
|||
1:2 |
<0.0053 |
<0.0053 |
<-2.28 |
<0.0054 |
|||
<0.0051 |
|||
Mean all±95% confidence interval |
|
<0.0081±0.0073 |
<-2.11±0.405 |
SD |
|
0.0030 |
0.163 |
Partition coefficients measured for Reactive Blue F08-0170 (Component 3)
Ratio of solvents (n-octanol : water) |
Partition coefficient |
Log Pow |
|
Pow |
Mean |
||
1:1 |
<0.0091 |
<0.0091 |
<-2.04 |
<0.0089 |
|||
<0.0092 |
|||
2:1 |
<0.0122 |
<0.0119 |
<-1.92 |
<0.0118 |
|||
<0.0118 |
|||
1:2 |
<0.0060 |
<0.0059 |
<-2.23 |
<0.0057 |
|||
<0.0059 |
|||
Mean all±95% confidence interval |
|
<0.0090±0.0075 |
<-2.07±0.384 |
SD |
|
0.0030 |
0.155 |
Partition coefficients measured for Reactive Blue F08-0170 (Component 4)
Ratio of solvents (n-octanol : water) |
Partition coefficient |
Log Pow |
|
Pow |
Mean |
||
1:1 |
<0.0035 |
<0.0035 |
<-2.45 |
<0.0036 |
|||
<0.0035 |
|||
2:1 |
<0.0046 |
<0.0047 |
<-2.33 |
<0.0047 |
|||
<0.0047 |
|||
1:2 |
<0.0025 |
<0.0024 |
<-2.62 |
<0.0023 |
|||
<0.0025 |
|||
Mean all±95% confidence interval |
|
<0.0035±0.0028 |
<-2.47±0.356 |
SD |
|
0.0011 |
0.143 |
Applicant's summary and conclusion
- Conclusions:
- In conclusion, the partition coefficient (Pow) of Reactive Blue F08-0170 in n-octanol-water was determined to be < 0.0096 +/- 0.0088 (95% confidence interval) using shake flask method.
Log Pow < -2.04 - Executive summary:
This study has been performed in accordance with the study plan, Directive of the European Communities: Methods for the Determination of Physico-Chemical Properties (A.8), Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for Testing of Chemicals, Guideline No. 107,”Partition Coefficient (n-octanol/water): Shake Flask Method”, adopted July 27, 1995 and the Principles of Good Laboratory Practice (GLP) and reported with a valid GLP certificate.
The purpose of this study was to determine the partition coefficient of Reactive Blue F08-0170. The test item is a reaction mass of 6 components. For this test only 4 of the main components were determined. The two remaining components are contained in a very low concentration, causing no effect on the results of the study.
In conclusion, the partition coefficient (Pow) of Reactive Blue F08-0170 in n-octanol-water was determined to be < 0.0096 ± 0.0088 (95% confidence interval) using shake flask method.
Log Pow: < -2.04
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