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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1995

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method B.6 (Skin Sensitisation)
Qualifier:
according to guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
GLP compliance:
yes (incl. QA statement)
Type of study:
guinea pig maximisation test

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(Trifluoromethyl)benzenesulfonamide
EC Number:
700-280-0
Cas Number:
1869-24-5
Molecular formula:
C7H6F3NO2S
IUPAC Name:
2-(Trifluoromethyl)benzenesulfonamide
Constituent 2
Reference substance name:
2-(Trifluoromethyl)benzenesulfonamide
IUPAC Name:
2-(Trifluoromethyl)benzenesulfonamide

In vivo test system

Test animals

Species:
guinea pig
Strain:
Pirbright-Hartley
Sex:
female

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
intradermal and epicutaneous
Vehicle:
olive oil
Concentration / amount:
Intradermal induction: Test substance 5 % in olive oil DAB 10 or in Freund's adjuvant (1:1) or olive oil DAB 10
Percutaneous induction: Test substance 50 % in olive oil DAB 10 or olive oil DAB 10
Challenge: Test substance 50 % in oilive oil 10 or olive oil DAB 10
Challengeopen allclose all
Route:
intradermal and epicutaneous
Vehicle:
olive oil
Concentration / amount:
Intradermal induction: Test substance 5 % in olive oil DAB 10 or in Freund's adjuvant (1:1) or olive oil DAB 10
Percutaneous induction: Test substance 50 % in olive oil DAB 10 or olive oil DAB 10
Challenge: Test substance 50 % in oilive oil 10 or olive oil DAB 10
No. of animals per dose:
Control group: 10
Test group: 20

Results and discussion

In vivo (non-LLNA)

Resultsopen allclose all
Reading:
other: Challenge
Hours after challenge:
24
Group:
other: Contol Group 1
Dose level:
50 %
No. with + reactions:
0
Total no. in group:
10
Remarks on result:
other: Reading: other: Challenge. . Hours after challenge: 24.0. Group: other: Contol Group 1. Dose level: 50 %. No with. + reactions: 0.0. Total no. in groups: 10.0.
Reading:
other: Challenge
Hours after challenge:
48
Group:
other: Control group 1
Dose level:
50 %
No. with + reactions:
0
Total no. in group:
10
Remarks on result:
other: Reading: other: Challenge. . Hours after challenge: 48.0. Group: other: Control group 1. Dose level: 50 %. No with. + reactions: 0.0. Total no. in groups: 10.0.
Reading:
other: Challenge
Hours after challenge:
24
Group:
test chemical
Dose level:
50 %
No. with + reactions:
0
Total no. in group:
20
Remarks on result:
other: Reading: other: Challenge. . Hours after challenge: 24.0. Group: test group. Dose level: 50 %. No with. + reactions: 0.0. Total no. in groups: 20.0.
Reading:
other: Challenge
Hours after challenge:
48
Group:
test chemical
Dose level:
50 %
No. with + reactions:
0
Total no. in group:
20
Remarks on result:
other: Reading: other: Challenge. . Hours after challenge: 48.0. Group: test group. Dose level: 50 %. No with. + reactions: 0.0. Total no. in groups: 20.0.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The TS does not have a sensitizing effect.