Tetradecyl chloroformate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards and is described in sufficient detail

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1983

Report date:

1983

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

limit dose was 5000 mg/kg bw

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Tetradecyl chloroformate

EC Number:

260-330-8

EC Name:

Tetradecyl chloroformate

Cas Number:

56677-60-2

Molecular formula:

C15H29ClO2

IUPAC Name:

tetradecyl carbonochloridate

Details on test material:

- Name of test material (as cited in study report): Myristylchlorformiat
- Physical state: liquid
- Analytical purity: no data

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Dr. K. Thomae GmbH
- Weight at study initiation: mean males: 189 g, mean females: 177 g
- Fasting period before study: feed was withdrawn 16 hours before administration
- Housing: 5 rats/cage
- Diet: SSNIFF no further data
- Water: ad libitum
- Acclimation period: at least one week


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24 °C
- Humidity (%): 30-70 %
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED:
5.3 ml/kg

Doses:

5000 mg/kg

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing was performed on day 0, day 2, day 7 and day 13; observations were performed frequently on the day of dosing and 1-2 daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Statistics:

not applicable

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Mortality:

no deaths occured, all 5 male and all 5 female animals survived the 14 days post dosing

Clinical signs:

other: none

Gross pathology:

organs without findings

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information

Conclusions:

The oral LD50 of Tetradecyl chlorformate was determined to be greater than 5000 mg/kg bw in rats.

Executive summary:

Tetradecyl chlorformate was administered to five male and five female Wistar rats at a dosage of 5000 mg/kg bw via gavage. Since there was no mortality observed in the treatment group within the 14 days observation period, the oral LD50 of the test substance was determined to be greater than 5000 mg/kg bw.