Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Basic data given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1957
Report date:
1957

Materials and methods

Principles of method if other than guideline:
other: BASF-Test
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Reference substance 001

Test animals

Species:
rabbit

Administration / exposure

Route of administration:
intravenous

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD100
Effect level:
ca. 93 mg/kg bw
Based on:
test mat.
Mortality:
Single i.v. application of the amine and the neutralized amine at a dose of 93 mg/kg bw led 100% lethality within several minutes. Single i.v. application of the amine at a dose of about 70 mg/kg bw led to lethality in some of the animals within several minutes. After single i.v. application ot the neutralized amine at a dose of about 46 mg/kg bw and of the neutralized hydrochloride at a dose of about 70 mg/kg bw the animals survived.

Applicant's summary and conclusion