Registration Dossier
Registration Dossier
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EC number: 269-323-4 | CAS number: 68223-93-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Justification for type of information:
- Not much information is available on toxicokinetics of thioclycolic acids and it salts, nor for DADTDG. For oral in vivo studies with administration via gavage, the stomach is the point of first contact of the substance. The acidity of gastric fluid catalyse hydrolysis, as well as oxidation. Degree of those reactions will have an impact on their further distribution, metabolism and toxic effects. To gain more information on transformation of thioglicolic acids, its salts and DADTDG, in vitro simulated gastric acid studies are planned for Q3 2022. The results of these studies will be used to reevaluate and strengthen the reas-across hypothesis selected for the analogue approach.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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