Registration Dossier
Registration Dossier
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EC number: 225-969-9 | CAS number: 5188-07-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 45 mg/kg bw/day
Additional information
In a combined repeated-dose/reproductive/developmental toxicity screening study (OECD TG 422), Sprague-Dawley rats (10/sex/dose) were administered 0, 5, 15 or 45 mg/kg bw/day of sodium methanethiolate in water by gavage daily at a volume of 5 ml/kg during an 8-week premating and mating periods until sacrifice for the males, or during a 4-week premating period, and through pregnancy and lactation, until day 4 post-partum, for the females (Gaoua, 2005). Females were paired with males from the same dose-level group until mating occurred or 2 weeks had elapsed. Gestation was monitored. Females were allowed to deliver normally and torear their progeny until day 5 post-partum. During the lactation period, the pups were examineddaily for survival and clinical signs and body weights were recorded on days 1 and 4 postpartum. At final sacrifice of the parents, specified organs were weighed and a complete macroscopic post-mortem examination was performed.
No substance-related effects were noted on the male and female reproductive performance and no indication of substance-induced developmental toxicity were observed at any dose levels.
The No Observed Effect Level (NOEL) for reproductive performance and developmental toxicity is established at 45
mg/kg/day.
Short description of key information:
In a combined repeated-dose/reproductive/developmental toxicity screening study (OECD TG 422) in rats, the No Observed Effect Level (NOEL) for reproductive performance and developmental toxicity is established at 45 mg/kg/day.
Justification for classification or non-classification
According to REGULATION (EC) No 1272/2008 and DIRECTIVE 67/548/EEC criteria and the available test, no classification is warranted for the reproductive toxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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