3-(trimethoxysilyl)propiononitrile

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

No data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1982

Report date:

1982

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

some study details missing, including TS purity.

Principles of method if other than guideline:

To investigate the potential toxicity of a single dose of the test substance.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-(trimethoxysilyl)propiononitrile

EC Number:

219-764-3

EC Name:

3-(trimethoxysilyl)propiononitrile

Cas Number:

2526-62-7

Molecular formula:

C6H13NO3Si

IUPAC Name:

3-(trimethoxysilyl)propanenitrile

Constituent 2

Reference substance name:

3-(trimethoxysilyl)propionitrile

IUPAC Name:

3-(trimethoxysilyl)propionitrile

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 200-300 g
- Fasting period before study: Yes, overnight
- Housing: No data
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: No data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data

IN-LIFE DATES: No data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: 16 ml/kg

Doses:

4, 8 and 16 ml/kg bw

No. of animals per sex per dose:

Five

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily, and weighing on days 0, 7 and 14.
- Necropsy of survivors performed: yes, gross examination.

Statistics:

LD50 calculated using moving average method.

Results and discussion

Effect levels

Effect levels 1

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

9.85 mL/kg bw

Based on:

test mat.

95% CL:

>= 7.15 - <= 13.6

Effect levels 2

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

11.3 mL/kg bw

Based on:

test mat.

95% CL:

>= 6.43 - <= 19.9

Mortality:

No deaths occurred in the lowest dose group. One male and one female died in the mid dose group (by day 5), and at the highest dose only one female survived the 14 day observation period (all animals died by six).

Clinical signs:

other: Signs of toxicity included sluggishness, unsteady gait and prostration.

Gross pathology:

Necropsy revealed gas, liquid or solid filled stomachs and intestines, enlarged kidneys and dark lungs.

Other findings:

None

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

In an acute oral gavage study, not conducted to GLP (reliability score 2), the oral LD50 for 3-(trimethoxysilyl)propionitrile in rats was 9.85 ml/kg bw for males and 11.3 ml/kg bw for females (9555 mg/kg bw and 10961 mg/kg bw, respectively, based on relative density of 0.97 g/cm3). Signs of toxicity included sluggishness, unsteady gait and prostration. Necropsy revealed gas, liquid or solid filled stomachs and intestines, enlarged kidneys and dark lungs.