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Previous Testing Proposals

Previous Testing Proposals

Previous Testing Proposals

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

 

Further information

 

For more information on these substances, please go to
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There are currently no ongoing consultations.
Page 16 of 41
50 Items per Page
Showing 751 - 800 of 2,011 results.
Name
EC Number
CAS Number
Hazard endpoint for which vertebrate testing was proposed
Date of publication to call for available information
Deadline for submitting information
Alternatives to vertebrate testing
 
Fluorobenzene 207-321-7 462-06-6
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
24/02/2020
24/02/2020
09/04/2020
09/04/2020
 Details
1,5-Diisocyanatopentane 807-040-5 4538-42-5 Long-term toxicity to fish 30/06/2023 14/08/2023 Details
2,2'-(cyclohexylimino)bisethanol 224-809-5 4500-29-2 Reproductive toxicity (pre-natal developmental toxicity) 17/09/2019 01/11/2019 Details
3-methylpentane-1,5-diol 224-709-1 4457-71-0 Long-term toxicity to fish 01/03/2023 17/04/2023 Details
Vinyl ethylene carbonate 700-261-7 4427-96-7 Sub-chronic toxicity (90-day): oral 30/06/2023 14/08/2023 Details
3-trimethoxysilylpropane-1-thiol 224-588-5 4420-74-0
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 3-(triethoxysilyl)propanethiol (EC 238-883-1) || Note: Testing proposal is based on concern identified by the registrant.
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 3-(triethoxysilyl)propanethiol (EC 238-883-1) || Note: Testing proposal is based on concern identified by the registrant.
23/11/2020
23/11/2020
07/01/2021
07/01/2021
 Details
3-trimethoxysilylpropane-1-thiol 224-588-5 4420-74-0 Long-term toxicity to fish||Note: testing proposed with 3-Triethoxysilylpropane-1-thiol (EC no. 238-883-1) 22/09/2022 07/11/2022 Details
4-morpholinecarbaldehyde 224-518-3 4394-85-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
10/05/2022
10/05/2022
27/06/2022
27/06/2022
 Details
4-morpholinecarbaldehyde 224-518-3 4394-85-8 Sub-chronic toxicity (90-day): oral 04/04/2014 19/05/2014 Details
2,2,4,4,6,8,8-heptamethylnonane 224-506-8 4390-04-9 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with two substances in a grouping approach: Icosane (EC 204-015-1) and Hydrocarbons, C14-C19, iso-alkanes, cyclics; aromatics <2% (920-114-2) 02/11/2018 17/12/2018 Details
Isohexadecane 2,2,4,4,6,8,8-heptamethylnonane 224-506-8 4390-04-9
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
10/05/2022
10/05/2022
27/06/2022
27/06/2022
 Details
(octahydro-4,7-methano-1H-indenediyl)bis(methylene) diacrylate 255-901-3 42594-17-2
Bioaccumulation test (Bioconcentration: Flow-through Fish Test)
Reproductive toxicity (pre-natal developmental toxicity)
23/03/2020
23/03/2020
07/05/2020
07/05/2020
 Details
(octahydro-4,7-methano-1H-indenediyl)bis(methylene) diacrylate 255-901-3 42594-17-2
Long-term toxicity to fish
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
22/04/2021
22/04/2021
22/04/2021
07/06/2021
07/06/2021
07/06/2021
 Details
zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) 224-235-5 4259-15-8
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
 Details
zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) 224-235-5 4259-15-8
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the substance and with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with the substance and with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8)
21/12/2021
21/12/2021
21/12/2021
04/02/2022
04/02/2022
04/02/2022
 Details
Di-tert-butyl trisulphide 224-226-6 4253-90-1 Long-term toxicity to fish 30/06/2023 14/08/2023 Details
Di-tert-butyl trisulphide 224-226-6 4253-90-1
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
01/03/2023
01/03/2023
01/03/2023
17/04/2023
17/04/2023
17/04/2023
 Details
methylsilanetriyl triacetate 224-221-9 4253-34-3 Sub-chronic toxicity (90-day): oral||Note: testing proposed with [triethoxy(methyl)silane] (CAS no. 2031-67-6) 03/10/2023 17/11/2023 Details
methylsilanetriyl triacetate 224-221-9 4253-34-3 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with [Trimethoxy(methyl)silane] (EC 214-685-0) 16/03/2015 30/04/2015 Details
3,3'-oxybis(ethyleneoxy)bis(propylamine) 224-207-2 4246-51-9
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2021
18/02/2021
05/04/2021
05/04/2021
 Details
Isononyl isononanoate 609-993-0 42131-25-9 Sub-chronic toxicity (90-day): oral 18/09/2014 03/11/2014 Details
2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate 224-116-8 4203-89-8 Genetic toxicity in vivo 23/03/2020 07/05/2020 Details
2,2-dimethylpropane-1,3-diyl dibenzoate 224-081-9 4196-89-8 Reproductive toxicity (pre-natal developmental toxicity) 29/02/2016 14/04/2016 Details
1,4-bis[(2-ethyl-6-methylphenyl)amino]anthraquinone 255-460-7 41611-76-1 Reproductive toxicity (pre-natal developmental toxicity) 04/04/2014 19/05/2014 Details
Sodium p-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzenesulphonate 223-989-2 4156-21-2 Sub-chronic toxicity (90-day): oral 29/04/2014 13/06/2014 Details
Sodium p-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzenesulphonate 223-989-2 4156-21-2 Reproductive toxicity (pre-natal developmental toxicity) 03/04/2023 22/05/2023 Details
Tris(p-isocyanatophenyl) thiophosphate 223-981-9 4151-51-3 6.1.2 Long-term toxicity to fish 08/03/2024 22/04/2024 Details
2,2-dimethylpropane-1,3-diyl cyclohex-4-ene-1,2-dicarboxylate 255-180-5 41026-17-9
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
16/05/2014
16/05/2014
30/06/2014
30/06/2014
30/06/2014
30/06/2014
 Details
2,2-dimethylpropane-1,3-diyl cyclohex-4-ene-1,2-dicarboxylate  255-180-5 41026-17-9
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
16/12/2016
16/12/2016
16/12/2016
30/01/2017
30/01/2017
30/01/2017
 Details
2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide 223-829-1 4090-51-1 Sub-chronic toxicity (90-day): oral 16/06/2022 01/08/2022 Details
3,6,9,12-tetraazatetradecamethylenediamine 223-775-9 4067-16-7
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with structural analogues TETA (CAS 90640-67-8) and HEPA (CAS 68121-73-7).
Reproductive toxicity (pre-natal developmental toxicity)
22/11/2017
22/11/2017
08/01/2018
08/01/2018
 Details
3,6,9,12-tetraazatetradecamethylenediamine 223-775-9 4067-16-7
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
28/02/2011
28/02/2011
14/04/2011
14/04/2011
 Details
1,3,5-tris[[4-tert-butyl-3-hydroxy-2,6-xylyl]methyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione 254-996-9 40601-76-1 Reproductive toxicity (pre-natal developmental toxicity) with Rat 24/07/2019 09/09/2019 Details
2-[(1-amino-9,10-dihydro-4-hydroxy-9,10-dioxo-2-anthryl)oxy]ethyl ethyl carbonate 254-959-7 40530-60-7 Genetic toxicity in vivo || Note: testing proposed with Disperse Red 302:1 (EC 248-882-8) 23/11/2020 07/01/2021 Details
2-(2-thienyl)ethyl toluene-p-sulphonate 254-911-5 40412-06-4 Genetic toxicity in vivo 06/09/2018 22/10/2018 Details
(2,4,6-trioxo-1,3,5-triazine-1,3,5(2H,4H,6H)-triyl)tri-2,1-ethanediyl triacrylate 254-843-6 40220-08-4 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant 19/10/2020 03/12/2020 Details
2,3-epoxypropyl isopropyl ether 223-672-9 4016-14-2 Genetic toxicity in vivo 19/10/2020 03/12/2020 Details
2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane 500-107-7 40039-93-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
27/09/2017
27/09/2017
27/09/2017
13/11/2017
13/11/2017
13/11/2017
 Details
2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate 254-588-0 39670-09-2
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
16/05/2014
16/05/2014
30/06/2014
30/06/2014
 Details
Phosphoric acid, octadecyl ester 254-466-7 39471-52-8
Long-term toxicity to fish
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant.
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
17/04/2015
17/04/2015
17/04/2015
17/04/2015
04/06/2015
04/06/2015
04/06/2015
04/06/2015
 Details
Nonane-1,9-diol 223-517-5 3937-56-2
Reproductive toxicity (extended one-generation reproductive toxicity study)
Sub-chronic toxicity (90-day): oral
05/07/2018
05/07/2018
20/08/2018
20/08/2018
 Details
Nonane-1,9-diol 223-517-5 3937-56-2
Reproductive toxicity (extended one-generation reproductive toxicity study)
Sub-chronic toxicity (90-day): oral
16/12/2020
16/12/2020
01/02/2021
01/02/2021
 Details
Phosphoric acid, dodecyl ester, potassium salt 254-414-3 39322-78-6
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/08/2014
14/08/2014
28/09/2014
28/09/2014
 Details
Sodium chloroacetate 223-498-3 3926-62-3 Reproductive toxicity (pre-natal developmental toxicity) 14/10/2011 28/11/2011 Details
Sodium chloroacetate 223-498-3 3926-62-3 Reproductive toxicity (two-generation reproductive toxicity) 16/06/2011 01/08/2011 Details
Bumetrizole 223-445-4 3896-11-5 Bioaccumulation aquatic / sediment 18/06/2018 02/08/2018 Details
2,6,10-trimethyldodecane 622-542-2 3891-98-3
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
18/02/2014
18/02/2014
18/02/2014
04/04/2014
04/04/2014
04/04/2014
 Details
(phenylethyl)benzene 254-179-7 38888-98-1 Reproductive toxicity (pre-natal developmental toxicity) 21/03/2014 05/05/2014 Details
[hexane-1,6-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid, potassium salt 254-135-7 38820-59-6
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/08/2014
14/08/2014
28/09/2014
28/09/2014
 Details
1,1'-(p-tolylimino)dipropan-2-ol 254-075-1 38668-48-3
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/03/2016
17/04/2015
28/04/2016
04/06/2015
 Details
Page 16 of 41
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Showing 751 - 800 of 2,011 results.