2,3-epoxypropyl phenyl ether

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable study which meets basic scientific principles.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Type of sensitisation studied:

skin

Study type:

study with volunteers

Principles of method if other than guideline:

Because of skin reaction of a laboratory worker using the test substance, the subject was challenged with this material to determine if sensitization had occurred. To provide a control for the positive reaction obtained with the test subject, a four-person panel (two men and two women) was treated the same way.

Test material

Test material information

Constituent 1

Reference substance name:

Propane, 1,2-epoxy-3-phenoxy

IUPAC Name:

Propane, 1,2-epoxy-3-phenoxy

Details on test material:

- Name of test material (as cited in study report): Propane, 1,2-epoxy-3-phenoxy
No further information.

Method

Type of population:

other: one worker, no information about the other subjects

Ethical approval:

not specified

Subjects:

- Number of subjects exposed: 5
- Sex: 3 men, 2 women
- Age: no data
- Race: no data
- Demographic information: no data

Clinical history:

- History of allergy or casuistics for study subject or populations: One subject, a worker using the test substance at workplace, was sensitized.

Controls:

2 men, 2 women

Route of administration:

dermal

Details on study design:

TYPE OF TEST(S) USED: patch test (epicutaneous test)

ADMINISTRATION
- Type of application: unocclusive
- Description of patch: 1 1/2 " x 1 1/2" 12-ply gauze patch held in place with Dermicel Tape for 6 hours
- Vehicle / solvent: ethanol
- Concentrations: 1:100, 1:1000, 1:10000
- Volume applied: one drop
No further information.

Results and discussion

Results of examinations:

SYMPTOMS
- Frequency, level, duration of symptoms observed: 4, 6, 24 and 72 hours after application

NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 1
- Number of subjects with negative reactions: 4

RESULT OF CASE REPORT: The worker, who was already sensitized, showed a definite allergic response with a reaction of 2+, erythema, edema and papules (not further specified).