Registration Dossier
Registration Dossier
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EC number: 270-472-2 | CAS number: 68441-68-9
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (OECD 211, D. magna); read-across
Key value for chemical safety assessment
Additional information
There is no study available investigating the long-term toxicity of Tetraesters of 2,2-bis(hydroxymethyl)propane-1,3-diol and decanoic and octanoic acid (CAS 68441-68-9) to aquatic invertebrates. Therefore, a read-across to the structurally related source substance Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) was conducted in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. Based on the high degree of similarity between the structural and physico-chemical properties of the target and source substances, the source substances are considered suitable representatives for the assessment of the short-term toxicity of the target substance to aquatic invertebrates. The read-across approach is justified in detail within the analogue justification in IUCLID section 13.
The available study was conducted according to OECD 211 and GLP. In a limit test, D. magna was exposed to a water accommodated fraction (WAF) of the test item with a nominal loading rate of 135 mg/L for 21 d under semi-static conditions. After 21 d, no significant effect on reproduction was observed in the treatment and the obtained NOELR (21 d) is ≥ 135 mg/L (nominal). Thus, no effects up to the limit of water solubility (< 0.05 mg/L) were observed.
Based on the available result from the structurally related source substance (in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5), it can be concluded that Tetraesters of 2,2-bis(hydroxymethyl)propane-1,3-diol and decanoic and octanoic acid (CAS 68441-68-9) will not exhibit short-term effects to aquatic invertebrates up to the limit of water solubility.
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