Bisbenzimidazo[2,1-b:2',1'-i]benzo[lmn][3,8]phenanthroline-8,17-dione

Partition coefficient

Administrative data

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

Procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer); method similar to Annex V, A.8, 1.6.1, Directive 67/548/EEC

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

test procedure similar to OECD 105

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

modified takint into account the very low solubility of the test substance

Principles of method if other than guideline:

Test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)

Type of method:

flask method

Water solubility:

7.2 µg/L

Temp.:

24 °C

pH:

ca. 7

_{The solubility of the sample C.I. Pigment Orange 43 in water at ambient temperature, determined under the conditions as mentioned above, is 7.2 µg per liter (mean, n = 3, sigma= 0.6).}

Table 1: Individual results

	Absorption (d = 1 cm)	µg/L
a1	0.00327	7.9
a2	0.00269	7.0
a3	0.00246	6.7

 

Conclusions:

The test substance is practically insolubly in water (< 0.1 mg/L)

Cross-reference 2

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

Test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

other: Analytical Expert Group ETAD

Principles of method if other than guideline:

Test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)

Medium:

n-octanol

Solubility:

13 µg/L

Temp.:

24 °C

Test substance stable:

yes

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2005

Report date:

2005

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: ETAD Analytical Expert Group

Version / remarks:

method for substances with very low solubility in both, water and n-octanol

Principles of method if other than guideline:

Based on the determined solubilities in water and in n-octanol the partition coefficient was estimated. Instead of saturated solvent
systems pure solvents were used.

Type of method:

estimation method (solubility ratio)

Partition coefficient type:

octanol-water

Test material

Test material information

Constituent 1

Reference substance name:

Bisbenzimidazo[2,1-b:2',1'-i]benzo[lmn][3,8]phenanthroline-8,17-dione

EC Number:

224-597-4

EC Name:

Bisbenzimidazo[2,1-b:2',1'-i]benzo[lmn][3,8]phenanthroline-8,17-dione

Cas Number:

4424-06-0

Molecular formula:

C26H12N4O2

IUPAC Name:

bisbenzimidazo[2,1-b:2',1'-i]benzo[lmn][3,8]phenanthroline-8,17-dione

Test material form:

solid: nanoform

Results and discussion

Partition coefficient

Partition coefficient 1

Type:

log Pow

Partition coefficient:

0.26

Temp.:

24 °C

pH:

ca. 7

Partition coefficient 2

Type:

Pow

Partition coefficient:

1.8

Temp.:

24 °C

pH:

ca. 7

Any other information on results incl. tables

Solubility of C.I. Pigment Orange 43 in n-octanol: 13.0 µg/L

Water solubility of C.I. Pigment Orange 43 : 7.2 µ/L

Applicant's summary and conclusion

Executive summary:

The log P_ow of C.I. Pigment Orange 43 is 0.26.