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Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2019-2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

2009

Deviations:

no

Principles of method if other than guideline:

Not applicable.

GLP compliance:

yes (incl. QA statement)

Remarks:

Inspected on 15-16/11/2017, Sigbned on 15/05/2018

Type of method:

static method

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

3 818 Pa

Key result

Test no.:

#2

Temp.:

25 °C

Vapour pressure:

4 838 Pa

Results

The calculation results are presented in the following table:

Calculated values for 1/T and log P

n	Temperature T	Pressure p	Temperature T	1/T	log p
	°C	hPa	K	1/K	log Pa
1	20.0	36.7	293.15	0.00341122	3.5647
2	27.9	55.0	301.05	0.00332171	3.7404
3	36.0	77.6	309.15	0.00323468	3.8899
4	43.7	111.8	316.85	0.00315607	4.0484
5	51.8	154.2	324.95	0.00307740	4.1881
6	59.7	203.3	332.85	0.00300436	4.3081
7	50.9	146.0	324.05	0.00308594	4.1644
8	42.0	103.0	315.15	0.00317309	4.0128
9	32.9	70.0	306.05	0.00326744	3.8451
10	23.4	44.9	296.55	0.00337211	3.6522
11	16.1	32.3	289.25	0.00345722	3.5092
12	12.2	26.2	285.35	0.00350447	3.4183

The parameters for the linear regression of the graph log (p) vs. 1/T are presented in the following table:

Linear Regression Parameters

Parameter	Value
Slope	-1797.612311
Intercept	9.713881271
Correlation coefficient r	-0.999638112
Coefficient of determination r^2	0.999276354

 

Using the equation which is stated, vapour pressures at ambient temperature were calculated as:

Calculated Values for vapour pressure

Parameter	Value	Unit
Vapour Pressure (20.0 °C)	3818	Pa
Vapour Pressure (25.0 °C)	4838	Pa

 

The vapour pressure was measured using the static method as described in EU method A.4. Twelve pairs temperature/vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature could be estimated.

From the measured values, the vapour pressure of the test item was calculated as 3818 Pa at 20.0 °C and 4838 Pa at 25.0 °C. The values of the heating and cooling down phase showed good correspondence.

Therefore, the result of the study is considered valid.

Conclusions:

Using the static method, vapour pressures of 3818 Pa at 20.0 °C and 4838 Pa at 25.0 °C were determined. These values represent the component with the highest vapour pressure.

Executive summary:

The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline, static method. Vapour pressures of 3818 Pa at 20.0 °C and 4838 Pa at 25.0 °C were determined.

These values were calculated from the regression of 12 individual measurements, which were performed in a temperature range of 12.2 – 59.7 °C.

The measured values for pressure p and temperature T were used to calculate pairs of log p and 1/T. These values were plotted, from the linear regression, vapour pressures at ambient temperature were determined.

Description of key information

Vapour pressures of 3818 Pa at 20.0 °C and 4838 Pa at 25.0 °C were determined (interpolation)

These values represent the component with the highest vapour pressure.

Key value for chemical safety assessment

Vapour pressure:

4 838 Pa

at the temperature of:

25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study.