Oxirane, 2,2'-[methylenebis[(2,6-dimethyl-4,1-phenylene)oxymethylene]]bis-

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

13 June 2006 to 05 July 2006

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

other: Column elution and Flask method

Key result

Water solubility:

0.001 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

6.4

Preliminary Test

The preliminary estimate of water solubility was 1.30 x 10^-3 g/L.

Column Elution Test

The mean peak areas relating to the standard and sample solutions are shown in the following table:

Solution	Mean Peak Area
Standard 1.01 mg/L	32.893
Standard1.00 mg/L	33.534
Sample A1	4.077
Sample B1	3.849
Standard 1.00 mg/L	33.453
Standard1.00 mg/L	33.97
Sample A2	3.327
Sample B2	2.953
Standard 1.01 mg/L	33.809
Standard 1.00 mg/L	33.849
Sample A3	3.022
Sample B3	2.678
Standard1.00 mg/L	33.643
Standard 1.00 mg/L	33.797
Sample A4	2.553
Sample B4	2.571
Standard 0.99 mg/L	33.414
Standard1.11 mg/L	38.117
Sample A5	1.271
Sample B5	0.646

The concentration (g/L) of test material in the sample solutions is shown in the following table:

Sample number	Sampling time (hour)		Concentration (g/L)		Solution pH
	Determination A	Determination B	Determination A	Determination B	Determination A	Determination B
1	66.25	33.75	2.47 x 10^-4	2.33 x 10^-4	6.8	7.1
2	91	71.25	1.98 x 10^-4	1.76 x 10^-4	7.0	7.0
3	115	115.25	1.80 x 10^-4	1.59 x 10^-4	6.8	6.9
4	139	139.25	1.51 x 10^-4	1.52 x 10^-4	7.1	7.0
5	235	235.25	7.45 x 10^-5	3.78 x 10^-5	6.8	7.0

 

Flask Test

The mean peak areas relating to the standard and sample solutions are shown in the following table:

Solution	Mean Peak Area
Standard 5.03 mg/L	145.587
Standard 5.03 mg/L	145.359
Sample1A	11.081
Sample1B	9.870
Sample 2A	10.537
Sample 2B	10.451
Sample 3A	10.761
Sample 3B	10.688

 

The concentration (g/L) of test material in the sample solutions is shown in the following table:

Sample number	Time shaken at 30 °C (hours)	Time equilibrated at 20 °C (hours)	Concentration (g/L)	Solution pH
1	1	1	7.22 x 10^-4	6.3
2	2	1	7.23 x 10^-4	6.5
3	3	1	7.39 x 10^-4	6.5

 

Mean concentration:  7.28 x 10^-4 g/L at 20.0 ± 0.5 °C

Conclusions:

Under the conditions of the study the water solubility of the test material was determined to be 7.28 x 10^-4 g/L of solution at 20.0 ± 0.5 °C.

Executive summary:

The water solubility of the test material was investigated in a study which was conducted in accordance with the standardised guideline EU Method A.6, under GLP conditions.

The determination was carried out using both the column elution method with a recirculating pump and the flask method.

Under the conditions of the study the water solubility of the test material was determined to be 7.28 x 10^-4 g/L of solution at 20.0 ± 0.5 °C.

Description of key information

Under the conditions of the study the water solubility of the test material was determined to be 7.28 x 10^-4 g/L of solution at 20.0 ± 0.5 °C.

Key value for chemical safety assessment

Water solubility:

0.001 g/L

at the temperature of:

20 °C

Additional information

The water solubility of the test material was investigated in a study which was conducted in accordance with the standardised guideline EU Method A.6, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

The determination was carried out using both the column elution method with a recirculating pump and the flask method.

Under the conditions of the study the water solubility of the test material was determined to be 7.28 x 10^-4 g/L of solution at 20.0 ± 0.5 °C.