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EC number: 270-472-2 | CAS number: 68441-68-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects to aquatic algae up to the limit of water solubility (OECD 201, S. capricornutum); read-across
Key value for chemical safety assessment
Additional information
There is no study available investigating the toxicity of Tetraesters of 2,2-bis(hydroxymethyl)propane-1,3-diol and decanoic and octanoic acid (CAS 68441-68-9) to aquatic algae. Therefore, read-across to the structurally related source substance Fatty acids, C8-10. mixed esters with dipenaterythritol, isooctanoic acid, pentaerythritol and tripentaerythritol (CAS 189200-42-8) was conducted in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. Based on the high degree of similarity between the structural and physico-chemical properties of the target and source substance, the source substance are considered suitable representatives for the assessment of the toxicity of the target substance to aquatic algae. The read-across approach is justified in detail within the analogue justification in IUCLID section 13.
The available study was conducted according to OECD 201 and GLP. In a static test, S. capricornutum was exposed to water accommodated fractions (WAFs) with nominal loading rates of 1000, 500, 250, 125 and 62.5 mg/L for 72 h. Test item concentrations were analytically verified by TOC in the 1000 mg/L treatment at the beginning (0 h) and at the end of the test (96 h).
The measured TOC in the WAF was 6.7 mg/L at 0 h and 4.2 mg/L after 4 h, which was in the same order of magnitude as the control with 5.4 mg/L at 0 h and 5.5 mg/L after 4 h, thus confirming the low solubility of the substance.
After 72 h of exposure no effects on the growth rate of the algae were observed and the derived effect concentrations are an EL50 (72 h) > 1000 mg/L (nominal) and a NOELR (72 h) ≥ 1000 mg/L. Thus, no effects up to the limit of water solubility (< 0.05 mg/L) were observed.
Based on the available result from the structurally related source substance (in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5), it can be concluded that Tetraesters of 2,2-bis(hydroxymethyl)propane-1,3-diol and decanoic and octanoic acid (CAS 68441-68-9) will not cause toxic effects to aquatic algae up to the limit of water solubility.
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