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EC number: 233-237-5 | CAS number: 10099-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication/study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Details on test material:
- - Name of test material (as cited in study report): Lanthanum nitrate 6*H2O
- Molecular formula (if other than submission substance): La(NO3)3 * 6H2O
- CAS No.: 10277-43-7
- Analytical purity: > 99%
Constituent 1
Method
- Target gene:
- his operon
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA100, TA1535, TA97, TA98
- Metabolic activation:
- with and without
- Metabolic activation system:
- Liver S-9 Fraction of Aroclor 1254-induced male Sprague-Dawley rat and Sprague-Dawley hamster. 10 and 30% S-9 mixes were tested.
- Test concentrations with justification for top dose:
- TA100/TA1535:
without and with activation (10% HLI, 10% RLI): 0, 3.3, 10, 33, 100 and 333 µg/plate;
with activation (30% HLI, 30% RLI): 0, 33, 100, 333, 1000 and 3333 µg/plate
TA97/TA98:
without activation and with activation (10% RLI): 0, 100, 333, 1000, 3333 and 10000 µg/plate
with activation (10% HLI, 30%HLI, 30% RLI): 0, 33, 100, 333, 1000 and 3333 µg/plate - Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: water
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: without metabolic activation: sodium azide (TA1535 and TAlOO), 9-aminoacridine (TA97), 4-nitro-o-phenylenediamine (TA98); with metabolic activation: 2-aminoanthracene for all strains.
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: preincubation
DURATION
- Preincubation period: 20 min.
- Exposure duration: 2 days
NUMBER OF REPLICATIONS: 3
DETERMINATION OF CYTOTOXICITY
- Method: relative total growth - Evaluation criteria:
- The colonies were machine counted unless precipitate was present. If precipitate were present, the colonies were counted visually. Mean values and standard deviations were calculated (three replicates).
A substance was judged mutagenic (+) or weakly mutagenic (+W) if it produced a reproducible, dose-related response over the solvent control, under a single metabolic activation condition, in replicate trials. A chemical was judged questionable (?) if the results of individual trials were not reproducible, if increases in his+ revertants did not meet the criteria for a “+W” response, or if only single doses produced increases in his+ revertants in repeat trials. It was not necessary for a response to reach two-fold over background for a trial to be judged mutagenic.
Chemicals were judged nonmutagenic (-) if they did not meet the criteria for a mutagenic or questionable response.
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA100, TA 1535, TA 97, TA98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- only observed with TA97 at 333 µg/plate and higher concentrations
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Mean number (with standard deviation, SEM) of revertants/plate with each bacterial strain:
(NA = without activation, HLI = liver S-9 fraction from hamster, RLI = liver S-9 frcation from rat, p = precipitate present in plates, x = precipitate present with toxicity, s = slight clearing of background lawn)
TA100 |
||||||||||
|
NA |
10% HLI |
30% HLI |
10% RLI |
30% RLI |
|||||
µg/plate |
mean |
sem |
mean |
sem |
mean |
sem |
mean |
sem |
mean |
sem |
0 |
94 |
4.7 |
124 |
3.4 |
137 |
8.5 |
105 |
7.4 |
132 |
4.7 |
3.3 |
94 |
8.0 |
120 |
2.0 |
|
|
122 |
9.1 |
|
|
10 |
93p |
1.7 |
111p |
13.5 |
|
|
132p |
1.5 |
|
|
33 |
102p |
7.5 |
116p |
8.5 |
147 |
7.5 |
123p |
11.8 |
143 |
7.2 |
100 |
101p |
6.4 |
107p |
3.5 |
116 |
1.5 |
121p |
5.2 |
141p |
3.3 |
333 |
97p |
0.9 |
113p |
4.4 |
143 |
7.6 |
112p |
10.1 |
149p |
2.2 |
1000 |
|
|
|
|
130p |
1.0 |
|
|
132p |
5.0 |
3333 |
|
|
|
|
117p |
7.3 |
|
|
106p |
5.8 |
pos |
746 |
19.2 |
302 |
13.5 |
679 |
12.3 |
755 |
18.2 |
1416 |
29.8 |
TA1535 |
||||||||||
|
NA |
10% HLI |
30% HLI |
10% RLI |
30% RLI |
|||||
µg/plate |
mean |
sem |
mean |
sem |
mean |
sem |
mean |
sem |
mean |
sem |
0 |
11 |
2.1 |
11 |
1.5 |
10 |
1.9 |
10 |
1.8 |
10 |
0.3 |
3.3 |
6 |
1.5 |
13 |
3.4 |
|
|
12 |
2.1 |
|
|
10 |
11p |
2.7 |
13p |
1.5 |
|
|
12p |
3.8 |
|
|
33 |
7p |
2.2 |
12p |
1.2 |
13 |
1.7 |
14p |
0.7 |
10 |
2.4 |
100 |
9p |
0.9 |
10p |
1.0 |
13 |
2.6 |
10p |
2.1 |
10 |
0.3 |
333 |
10p |
0.7 |
11p |
0.6 |
9p |
1.8 |
10p |
0.6 |
13p |
1.5 |
1000 |
|
|
|
|
12p |
2.1 |
|
|
8p |
0.7 |
3333 |
|
|
|
|
10p |
0.9 |
|
|
8p |
0.9 |
pos |
385 |
17.3 |
39 |
4.8 |
96 |
10.7 |
184 |
6.2 |
156 |
15.5 |
TA97 |
||||||||||
|
NA |
10% HLI |
30% HLI |
10% RLI |
30% RLI |
|||||
µg/plate |
mean |
sem |
mean |
sem |
mean |
sem |
mean |
sem |
mean |
sem |
0 |
127 |
8.7 |
114 |
11.7 |
156 |
13.0 |
115 |
3.2 |
199 |
2.8 |
33 |
|
|
128p |
5.3 |
161 |
4.8 |
|
|
184 |
3.7 |
100 |
127p |
1.0 |
123p |
9.9 |
159 |
6.7 |
79p |
4.6 |
163p |
12.2 |
333 |
131p |
2.0 |
105p |
10.1 |
155p |
3.8 |
92p |
4.6 |
129p |
3.8 |
1000 |
119p |
7.1 |
94p |
7.0 |
122p |
5.2 |
109p |
0.9 |
118p |
1.0 |
3333 |
99p |
4.3 |
86x |
3.9 |
99p |
6.4 |
80p |
6.6 |
118p |
9.4 |
10000 |
86x |
2.0 |
|
|
|
|
60p |
7.5 |
|
|
pos |
260 |
19.5 |
1078 |
29.4 |
1088 |
24.1 |
2819 |
19.2 |
1016 |
13.2 |
TA98 |
||||||||||
|
NA |
10% HLI |
30% HLI |
10% RLI |
30% RLI |
|||||
µg/plate |
mean |
sem |
mean |
sem |
mean |
sem |
mean |
sem |
mean |
sem |
0 |
41 |
5.9 |
31 |
3.5 |
37 |
1.5 |
29 |
5.8 |
32 |
1.5 |
33 |
|
|
35 |
1.9 |
27 |
4.5 |
|
|
32 |
3.5 |
100 |
31p |
4.9 |
38 |
4.9 |
27 |
1.0 |
32 |
1.7 |
30 |
0.3 |
333 |
37p |
4.4 |
34 |
4.1 |
26p |
1.7 |
33 |
4.7 |
36 |
1.2 |
1000 |
48p |
2.3 |
28p |
4.0 |
26p |
3.5 |
32 |
4.1 |
32 |
3.0 |
3333 |
45s |
5.6 |
27p |
3.8 |
26p |
4.1 |
25p |
0.3 |
29p |
2.3 |
10000 |
37s |
2.8 |
|
|
|
|
30p |
3.6 |
|
|
pos |
313 |
30.7 |
201 |
22.0 |
149 |
0.0 |
350 |
24.6 |
486 |
17.3 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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