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Diss Factsheets
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EC number: 201-116-6 | CAS number: 78-42-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa-term.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological Studies on Tri-(2-Ethylhexyl)-Phosphate
- Author:
- MacFarland H.N.; Punte C.L.
- Year:
- 1 966
- Bibliographic source:
- Archives of Environmental Health Vol. 13, pp.13-20
Materials and methods
- Principles of method if other than guideline:
- other: repeated dose toxicity inhalation study in guinea pigs
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Tris(2-ethylhexyl) phosphate
- EC Number:
- 201-116-6
- EC Name:
- Tris(2-ethylhexyl) phosphate
- Cas Number:
- 78-42-2
- Molecular formula:
- C24H51O4P
- IUPAC Name:
- tris(2-ethylhexyl) phosphate
- Details on test material:
- Mol wt: 434.6;
Sp g: 0.925 at 20 C;
n25D: 1.4473;
Surface tension: 31 dynes/sq cm;
Viscosity: 10.2 cp;
Vap press: 2 mm Hg at 200 C
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: no data
- Remarks on MMAD:
- MMAD / GSD: 3.8µ, with a geometric standard deviation of 1.7
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 3 months
- Frequency of treatment:
- 6h/d, 5d/w
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1.6 and 9.6 mg/m³
Basis:
analytical conc.
- No. of animals per sex per dose:
- 20
- Control animals:
- yes
- Details on study design:
- Post-exposure period: no
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- effects observed, treatment-related
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- ca. 9.6 mg/m³ air
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
at high level significantly increased terminal body weight,
no significant alteration in red blood cell and plasma
cholinesterase activity, no abnormalties at necropsy,
microscopic examination revealed inconsistent and
reversible changes of renal parenchyma of the high level
group, sections of the spinal cord and sciatic nerve stained
to demonstrate the myelin sheaths showed no pathologic
alteration.
Applicant's summary and conclusion
- Executive summary:
In an old and limited documented 3 month repeated inhalation study in guinea pigs performed in the same laboratory two different concentrations of test substance aerosol were used in three chambers ( 1.6 and 9.6 mg/m³); the third served as control. The animals were exposed for six hours a day, five days per week, to a total of 60 exposures. Two deaths were recorded, one in the control and one in the low level test substance group; both deaths occurred during the ninth week of exposure. The only gross sign observed was piloerection, seen in both control and treated groups throughout the 12 -week period. Body weights decreased in all three groups during the first week of exposure but steadily increased in the succeeding weeks. The mean kidney weight to body weight ratio for both test substance groups was significantly lower than that of the control group. No significant differences were found in the red blood cell and plasma cholinesterase activities between the control group and either of the treated groups. Gross pathological examination of the two guinea pigs which died during the ninth week of exposure showed extensive consolidation of lung tissue. When the surviving animals were sacrificed at the end of the 12 week´s exposure, midly congested lungs were noted in a quarter of the guinea pigs in the control group, but no abnormalities were found in the test substance treated animals. Microscopic examination of the tissue revealed only inconsistent and apparently reversible changes in the renal parenchyma of the high level test substance groups. Histopathological alterations in the lung and liver were confined to those due to coincidental disease. Sections of the spinal cord and sciatic nerve stained to demonstrate the myelin sheaths showed no pathologic alteration.
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