Registration Dossier
Registration Dossier
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EC number: 601-431-2 | CAS number: 1164-92-7
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- yes
- Remarks:
- restrictions in documentation and reporting
- GLP compliance:
- no
- Type of method:
- HPLC method
Test material
- Reference substance name:
- 17 beta-Acetoxy-5 alpha-androstan-3-one
- EC Number:
- 601-431-2
- Cas Number:
- 1164-92-7
- Molecular formula:
- C21 H32 O3
- IUPAC Name:
- 17 beta-Acetoxy-5 alpha-androstan-3-one
Constituent 1
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 4.9
- Temp.:
- 25 °C
- pH:
- ca. 7
- Remarks on result:
- other: pH of aqueous part HPLC eluent
Applicant's summary and conclusion
- Executive summary:
The n-octanol/water partition coefficient of Androstanolon-acetat was determined at 25°C according to EU testing method A.8, following OECD Testing Guideline 117 (HPLC method) to be (at 25°C, pH7):
log Pow= 4.9 (95 % confidence limits 4.6 to 5.1)
This method is based on the correlation of the reversed phase retention data of the test compound with those of reference compounds with known log Pow values
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