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Diss Factsheets
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EC number: 204-614-1 | CAS number: 123-28-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP study with limited but sufficient documentation
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The Fate of [l4C]Thiodipropionates in Rats
- Author:
- Reynolds, R.C., Astill, B. D., and Fassett, D.W.
- Year:
- 1 974
- Bibliographic source:
- Toxicology and applied pharmacology 28, 133-141 (1974)
- Reference Type:
- secondary source
- Title:
- Final Report on the Safety Assessment of Dilauryl Thiodipropionate
- Author:
- Liebert MA
- Year:
- 1 992
- Bibliographic source:
- Journal of the american college of toxicology
- Reference Type:
- secondary source
- Title:
- Final Safety Assessment of Thiodipropionic Acid and Its Dialkyl Esters as Used in Cosmetics
- Author:
- Diamante C et al.
- Year:
- 2 011
- Bibliographic source:
- International Journal of Toxicology 29 (Supplement 3) 137S-150S
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 417 (Toxicokinetics)
- Deviations:
- yes
- Remarks:
- limited reporting details
- Principles of method if other than guideline:
- The fate of the test substance (didodecyl thiodipropionate (carboxy 14C-labeled, [14C]DDTDP) after oral application to rats was investigated.
- GLP compliance:
- no
Test material
- Reference substance name:
- Didodecyl 3,3'-thiodipropionate
- EC Number:
- 204-614-1
- EC Name:
- Didodecyl 3,3'-thiodipropionate
- Cas Number:
- 123-28-4
- Molecular formula:
- C30H58O4S
- IUPAC Name:
- didodecyl 3,3'-sulfanediyldipropanoate
- Details on test material:
- Carboxy 14C-labeled didodecyl thiodipropionate ([14C]DDTDP), specific activity 60 microCi/mmol, was purified (99.2 % by chromatography) by recrystallization from aqueous acetone.
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 215 - 325 g
- Housing: in glass metabolism cages, for collection of urine, faeces and exhaled carbon dioxide
- Fasting period before study: yes (animals were starved prior to dosing)
- Water (ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Administration / exposure
- Route of administration:
- other: oral in feed, and oral by gavage
- Vehicle:
- other: see details on exposure
- Details on exposure:
- In some experiments the dose was incorporated into powdered Purina Lab Chow (20 mesh), homogenized hen’s egg (1 egg/50 g) and water to a stiff
paste which was heated and formed into sticks (10 - 12 g).
In other experiments, didodecylthiodipropionate was dissolved in corn oil and applied by gavage. - Duration and frequency of treatment / exposure:
- single treatment, for both gavage and feed administration (concerning feed: after 4-8 hr any unconsumed dose of the prepared feed was removed and rats were returned to the regular diet)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
107 and 208 mg/kg bw (gavage), 166 mg/kg bw (feed)
- No. of animals per sex per dose / concentration:
- 1
- Control animals:
- no
- Positive control reference chemical:
- not required
- Details on study design:
- Elimination of the radiolabelled test substance via urine, faeces and CO2 was investigated by scintillation spectrometry, scintillation assay/planchets or in a scintillation spectrometer, respectively. Internal organs were homogenized in acetone, residues collected and dried and afterwards assayed in a Thomas-Ogg apparatus and also counted in a scintillation spectrometer.
Metabolites were isolated of urine by acid and enzymatic hydrolysis. - Details on dosing and sampling:
- For feed application, rats were kept in the metabolism cages for 34 days.
For gavage application, rats were kept in the metabolism cage for 4 days or 8 days.
Urines and CO2 absorbers were processed daily. Liver, kidneys, brain, heart, lungs, whole gastrointestinal tracts and fat samples were removed at sacrifice and frozen with carcasses until assayed. - Statistics:
- not applicable
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- The test substance was almost entirely absorbed from the gastrointestinal tract at fed levels of up to 208 mg/kg bw, respectively.
- Type:
- distribution
- Results:
- Low amounts of the test substance was found in fat tissues at the last sacrifice on day 34.
- Type:
- metabolism
- Results:
- the test substance was excreted in urine as free or as acid labile conjugate
- Type:
- excretion
- Results:
- mostly via urine (85 - 88 %), with less in faeces (1. 8- 3.5 %) and as carbon dioxide (3 - 4 %)
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The test substance was almost entirely absorbed from the gastrointestinal tract at fed levels up to 208 mg/kg bw, respectively.
- Details on distribution in tissues:
- Distribution in tissues was close to normal values except the value of radioactivity in the fat was elevated at 4 days after dosing and remained so at 8 and 34 days. Data is given for liver, kidney, brain, heart, lung, gastrointestinal tract, fat and carcass.
- Details on excretion:
- Urinary elimination accounts for about 90% of the dose. Elimination in faeces and carbon dioxide accounts for ca 2-4% and 3-4% of the dose, respectively. More than 90% of the dose is eliminated within the first 24h. This data is given as a graph. The test substance appears to be almost completely eliminated within 3 days.
Acid hydrolysis of urine samples afforded high rates of recovery approaching 100% of the urinary radioactivity after feeding.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Dithiopropionic acid was recovered in urine free or as a acid-labile conjugate.
Any other information on results incl. tables
Table 1: Cumulative elimination in the rat after gavage and feed application
Compound | Rat no. | dose [mg/kg bw] | dose [μCi] | gavage/feed | time [days] | Elimination | |||
urine | carbon dioxide | faeces | total | ||||||
Thiodipropionic acid | 1 | 3.1 | 9.3 | gavage | 4 | 90.10% | 3.10% | 0.50% | 93.60% |
2 | 650 | 9 | gavage | 4 | 78.10% | 8.20% | 0.50% | 86.80% | |
3 | 572 | 9.3 | gavage | 4 | 84.50% | 2.80% | 0.90% | 88.40% | |
4 | 551 | 8.9 | gavage | 8 | 88.50% | 7.20% | 0.20% | 95.90% | |
5 | 241 | 8.2 | feed | 34 | 87.40% | 3.30% | 0.10% | 90.70% | |
Didodecyl thiodipropionate | 1 | 107 | 3.3 | gavage | 4 | 84.60% | 2.90% | 3.50% | 90.90% |
2 | 208 | 6.6 | gavage | 8 | 88.50% | 3.90% | 1.80% | 94.40% | |
3 | 166 | 4 | feed | 34 | 86.10% | 3.20% | 0.10% | 89.40% |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.