Registration Dossier
Registration Dossier
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EC number: 231-600-2 | CAS number: 7647-17-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with the Guidance on Information Requirements and Chemical Saftey Assessment, chapter R.7c (ECHA, 2008) the profile on basic toxicokinetics of cesium chloride was derived from physico-chemical data as well as from toxicological data of cesium chloride and structurally related cesium salts.
Due to its physico-chemical properties and the observed systemic toxicity at least at high concentrations cesium chloride more precisely the two respective ions will be well absorbed within the GI tract and become bioavailable following oral administration. This estimation is confirmed by literature data.
Based on its physico-chemical properties and absence of toxicity in acute dermal toxicity studies very limited absorption into the systemic circulation is expected after dermal application. Literature data support this estimation.
Due to its physico-chemical properties and absence of toxicity in acute dermal toxicity studies very limited absorption into the systemic circulation is expected after dermal application. Literature data support this estimation.
Considering the physico-chemical properties it is unlike that the substance will be inhaled either in vapour form or as dust particles under use conditions.
Based on the physico-chemical properties the respective ions of cesium chloride are readily distributed throughout the body. This is confirmed by the presence of target organs in subacute and subchronic studies and literature data.
Due to the physico-chemical properties and according to available literature it is not likely that cesium chloride will undergo further enzymatic biotransformation processes or will reveal an accumulation potential.
Considering the physic-chemical properties and the available literature cesium chloride is mainly urinary excreted.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
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