Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 244-691-9 | CAS number: 21981-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa-term.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study in accordance to OECD GL
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 1,1,1,3,3-pentachlorobutane
- EC Number:
- 244-691-9
- EC Name:
- 1,1,1,3,3-pentachlorobutane
- Cas Number:
- 21981-33-9
- Molecular formula:
- C4H5Cl5
- IUPAC Name:
- 1,1,1,3,3-pentachlorobutane
- Details on test material:
- - Name of test material (as cited in study report): 1,1,1,3,3-pentachlorobutane
- Molecular formula (if other than submission substance): same as submission substance
- Molecular weight (if other than submission substance): same as submission substance
- Smiles notation (if other than submission substance): same as submission substance
- Substance type: organic
- Physical state: liquid
- Analytical purity: 90%
- Purity test date: 09/09/99
- Lot/batch No.: 99350L08
- Expiration date of the lot/batch: 13/09/2000
- Stability under test conditions: stable
- Storage condition of test material: at room temeprature in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland
- Age at study initiation: 10-13 weeks old
- Weight at study initiation: males 360-470 g; females 200-270 g
- Fasting period before study: overnight befoere dosing up to 3-4 hours after dosing
- Housing: individual housing in the pilot study and group housing of 5 rats/sex/cage in the main study
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21°C
- Humidity (%): 30-70%
- Air changes (per hr): 15/h
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From:26/10/99 To: 10/12/99
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: Vehicle was used only for the lowest concentration tested (50 mg/kg bw). the test substance was dosed uin the vehicle at a concentration of 25 mg/ml
- Amount of vehicle (if gavage): 2ml/kg
- Justification for choice of vehicle: selected based on a pretest carried out at Notox
- Lot/batch no. (if required): not reported
- Purity:
MAXIMUM DOSE VOLUME APPLIED: 5000 mg/kg - Doses:
- 5000, 2000, 500 and 50 mg/kg
- No. of animals per sex per dose:
- pilot study: 1 female at 5000 mg/kg
main study: 5 rat/sex at 5000 mg/kg, 2 rats/sex at 2000 and 50 mg/kg, 5 rats/sex at 50 mg/kg - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations: at fixed intervals on day 1, daily during the observation period; body weighing: day 1, 2, 3, 4, 8 and 15 and at death (if after day 1)
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, necropsy - Statistics:
- not performed
Results and discussion
- Preliminary study:
- 1 female rat dosed at 5000 mg/kg was killed moribund on day 4.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 50 - < 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 10/10 rats dosed at 5000 mg/kg died within day 2. 2/2 rats dosed at 2000 mg/kg and 500 mg/kg died within day 3 and 4, respectively. No mortality was observed at 50 mg/kg
- Clinical signs:
- other: Lethargy, hunched posture, uncoordinated movements, ptosis, clonic spasms and ventrolateral recumbency were the most common observations reported for animals dosed at >=500 mg/kg. At 50 mg/kg uncoordinated movements were observed in 2 females on day 1, bu
- Gross pathology:
- Severe lesions were observed in the stomach at >= 500 mg/kg. Among them Irregular surface of the glandular mucosa and dark red foci, thickening and hemorrages in the glandular mucosa were reported.
No macroscopic abnormalities were observed at 50 mg/kg.
Any other information on results incl. tables
The incidence of mortality was:
5000 mg/kg: 5/5 males and 5/5 females
2000 mg/kg: 2/2 females
500 mg/kg: 2/2 females
50 mg/kg: 0/5 males and 0/5 females
Clinical signs:
5000 mg/kg: Lethargy, hunched posture, uncoordinated movements, piloerection, ptosis, clonic spasms and/or ventro lateral recumbency.
2000 mg/kg: Lethargy, hunched posture, uncoordinated movements, piloerection, ptosis, clonic spasms, ventro lateral recumbency and/or animal was pale.
500 mg/kg: Lethargy, hunched posture, piloerection, clonic spasms, alopecia and/or red stainingof the snout
50 mg/kg: Uncoordinated movements in 2 females on day 1. No clinical signs noted in the other male and female rats. Pathology 5000 mg/kg: Stomach, irregular surface of the glandular mucosa and dark red foci. Mesenteric lymph node, dark red foci. Thymus, dark red foci. 2000 mg/kg: Stomach, thickening of the limiting ridge and hemorrages of the glandular mucosa. Kidney, dark red discolouration of the medulla. 500 mg/kg: Stomach, irregular surface of the glandular mucosa, thickening. Thymus, reduced in size. 50 mg/kg: no abnormality recorded.Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the mortality results, the LD50 was determined within the range 50-500 mg/kg.
The study results warrant a classification as Xn R22 (harmful if swallowed) under Directive 67/548/EEC and as Acute toxicity Category 3 (H301: Toxic if swallowed) under Regulation (EC) No 1272/2008. - Executive summary:
The oral acute toxicity of 1,1,1,3,3 -pentachlorobutane was assessed by means of a fixed dose method.
Rats were dosed at 5000, 2000, 500 and 50 mg/kg. Mortality was observed at >=500 mg/kg, with a LD50 determined within the range 50 -500 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)