Registration Dossier
Registration Dossier
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EC number: 609-106-7 | CAS number: 35249-89-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study result has been reported in a review and it was not possible to evaluate the original study.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final report on the safety assessment of glycolic acid, ammonium, calcium, potassium, and sodium glycolates, methyl, ethyl, propyl, and butyl glycolates, and lactic acid, ammonium, calcium, potassium, sodium and tea-lactates, methyl, ethyl, isopropyl, and
- Author:
- Cosemtic Ingredient Review
- Year:
- 1 998
- Bibliographic source:
- International Journal of Toxicology, 17(Suppl. 1):1-3,1998
Materials and methods
- Principles of method if other than guideline:
- Method not published
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Glycollic acid
- EC Number:
- 201-180-5
- EC Name:
- Glycollic acid
- Cas Number:
- 79-14-1
- Molecular formula:
- C2H4O3
- IUPAC Name:
- glycol acid
- Reference substance name:
- 2-hydroxyacetic acid
- IUPAC Name:
- 2-hydroxyacetic acid
- Reference substance name:
- Glycolic acid
- IUPAC Name:
- Glycolic acid
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 950 mg/kg bw
- Based on:
- other: lactic acid 5% water solution
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 600 - 3 200 mg/kg bw
- Based on:
- other: lactic acid 20% water solution
Applicant's summary and conclusion
- Conclusions:
- The LD50 of a 5% and a 20% aqueous solution of lactic acid in rats is 1950 mg/kg bw/day and 1600-3200 mg/kg bw/day, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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