Registration Dossier
Registration Dossier
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EC number: 234-205-3 | CAS number: 10595-60-5
Endpoint summary
Administrative data
Description of key information
Skin: corrosive (US EPA, 1991)
Eye: serious eye damage (US EPA, 1991)
Key value for chemical safety assessment
Additional information
Skin irritation
A skin irritation study was conducted on three male and three female albino rabbits. One intact skin test site and one abraded skin test site per rabbit were each treated with 0.5 ml of actual undiluted test material and occluded for 24 hours. Observations for dermal irritation or defects were made 24 and 72 hours after treatment.
The undiluted test material produced an average erythema score of 3.92 (intact skin) and an average edema score of 4.0 (intact skin). Fullthickness necrosis was present on each test site at each observation time. The test substance was therefore corrosive to the skin.
Eye irritation
An eye irritation study was conducted on nine albino rabbits. 0.1 ml of actual undiluted test material was placed at room temperature in the conjunctival sac of the right eye of each animal selected for testing. The treated eyes of three of the animals were each washed with 300 ml of room temperature tap water beginning 30 seconds after treatment.
The undiluted test material produced corneal ulceration in six unwashed eye, conjunctival necrosis in six unwashed eyes. The undilzted test material produced corneal ulceration in three washed eyes, conjunctival necrosis in three washed eyes .
The mean scores (24/48/72 hours) for the unwashed eyes were 2 .67 for corneal opacity, 2 for iris lesions, 2.28 for conjunctival redness and 4 for edema. These effects were not reversible within the observation period of 7 days. The test substance therefore poses the risk of causing serious damage to the eye.
Justification for classification or non-classification
Based on the available skin and eye irritation studies, the substance has to be classified R 34 (Directive 67/548/EEC) and skin corrosion Cat 1C (CLP). This automatically implies a classification with R41 (Directive 67/548/EEC) and eye irritant Cat. 1 (CLP).
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