Registration Dossier
Registration Dossier
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EC number: 839-928-3 | CAS number: 174072-89-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- QSAR prediction.
Data source
Reference
- Reference Type:
- other: QSAR prediction
- Title:
- Unnamed
- Year:
- 2 022
- Report date:
- 2022
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6 May/July 2008
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl 2-amino-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate
- EC Number:
- 839-928-3
- Cas Number:
- 174072-89-0
- Molecular formula:
- C14H14N2O4S
- IUPAC Name:
- Ethyl 2-amino-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate
- Test material form:
- solid: crystalline
Constituent 1
Test animals / tissue source
- Species:
- other: not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- other: maximum mean average score
- Score:
- 21.9
- Remarks on result:
- other: QSAR Toolbox
Applicant's summary and conclusion
- Interpretation of results:
- Category 2B (mildly irritating to eyes) based on GHS criteria
- Conclusions:
- According to (Q)SAR model using QSAR Toolbox 4.5 the predicted MMAS value of Ethyl 2-amino-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate is 21.9.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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