Registration Dossier
Registration Dossier
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EC number: 614-648-2 | CAS number: 68606-83-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- experimental study
- Remarks:
- Appraisal of sensitizing potential of Cananga Oil by maximisation testing.
- Adequacy of study:
- key study
- Study period:
- 14/06/1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Guideline:
- other: Guideline not stated in report. Lab study on 25 healthy volunteers on the skin sensitisation of Cananga Oil.
- GLP compliance:
- yes
- Type of study:
- not specified
Test material
- Reference substance name:
- Essential oil of Cananga odorata ext. obtained from the flowers of Cananga odorata macrophylla by steam distillation
- Cas Number:
- 68606-83-7
- IUPAC Name:
- Essential oil of Cananga odorata ext. obtained from the flowers of Cananga odorata macrophylla by steam distillation
1
Results and discussion
In vitro / in chemico
Results
- Key result
- Group:
- test chemical
- Run / experiment:
- mean
- Parameter:
- other: Sodium Lauryl Sulfate Pre-treatment if required.
- Value:
- 0
- Remarks on result:
- no indication of skin sensitisation
- Remarks:
- All 25 volunteers showed no sign of skin sensitisation when Cananga oil was used.
- Outcome of the prediction model:
- no or minimal reactivity [in chemico]
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Remarks:
- No Skin sensitisation seen in the study.
- Conclusions:
- Cananga oil possesses no skin sensitisation properties.
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