Registration Dossier
Registration Dossier
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EC number: 266-235-8 | CAS number: 66204-44-2
Endpoint summary
Administrative data
Description of key information
In an older skin irritation study (Leuschner 1976), reversible irritant effects were reported in rabbits exposed for 24 h (4 h recommended) to the neat test substance.
The results of this study are in contrast to the findings of corrosivity in two other studies, probably because the test substance was not applied directly to the skin. Schülke & Mayr. Consultex 1979 also exposed rabbits for 24 h. There was evidence that the test substance causes burns after this exposure period. No data were available on the reversibility of these effects (limited documentation) but it can be concluded from this study that the test substance has corrosive properties. In a 3rd study conducted according to OECD guideline 404 (Vaeth 2002), 4 h dermal exposure to 0.5 mL test substance resulted in destruction of skin tissue.
In an acute eye irritation study in 3 rabbits (comparable to OECD guideline 405; Consultex 1979), the application of 0.1 mL of the undiluted test substance resulted 24 h after instillation in severe ocular reactions which are presumed to be permanent. In view of these effects the animals were sacrificed 24 hours after instillation. In a 2nd experiment the eye was exposed for 4 seconds and then washed with 20 mL lukewarm water. Despite the short exposure duration similar results were obtained and rabbits were also sacrificed 24 hours after instillation. No irritant effects were detected after instillation of 0.1 ml 0.2% aqueous solution.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The neat test substance has corrosive properties. The substance diluted in aqueous solution at a concentration of 5% resulted in slight skin irritation, no effects were detected at 1%.
As expected from skin irritation studies the neat test substance was corrosive to the eyes.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Proposal for classification and labelling of the substance: C; R34 (causes burns).
According to GHS: Skin corrosion 1b, Eye damage 1
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