p-menth-1-en-8-ol

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

toxicity to microorganisms, other

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1978

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Qualifier:

equivalent or similar to guideline

Guideline:

other: OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))

Deviations:

yes

Remarks:

(test duration lower than 28 d)

GLP compliance:

no

Analytical monitoring:

yes

Details on sampling:

- Concentrations: 100 mg/L

Vehicle:

no

Test organisms (species):

activated sludge

Details on inoculum:

- Initial biomass concentration: 30 mg/L SS

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

2 wk

Nominal and measured concentrations:

100 mg/L (nominal)

Details on test conditions:

TEST SYSTEM
- Sludge concentration (weight of dry solids per volume): 30 mg/L.
- Nitrification inhibitor used (delete if not applicable): none.

OTHER TEST CONDITIONS
- Adjustment of pH: no.

EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Biodegradation % based on oxygen consumption.

TEST CONCENTRATIONS
- Test concentrations: 100 mg/L

Reference substance (positive control):

not specified

Key result

Duration:

14 d

Dose descriptor:

NOEC

Effect conc.:

100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: Readily biodegradability

Details on results:

The NOEC of the test item was determined to be 100 mg/L since the substance degrades well (84.6% of biodegradation at 14 days).

Validity criteria fulfilled:

not specified

Conclusions:

The NOEC (14d) for microorganism toxicity of the test item was determined to be 100 mg/L (based on biodegradation).

Executive summary:

A ready biodegradability test was perfomed on alpha terpineol. The test item was incubated for 14 days at a concentration of 100 mg/L with 30 mg/L SS activated sludge inoculum under aerobic conditions in a mineral medium. The NOEC (14d) of the test item was determined to be 100 mg/L since the substance degraded well (84.6% of biodegradation at 14 days).

Reference 2

Endpoint:

toxicity to microorganisms, other

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue substance alpha terpineol which shares the same functional groups with the substance L-alpha terpineol also has comparable values for the relevant molecular properties.
See attached the reporting format.

Reason / purpose for cross-reference:

read-across source

Key result

Duration:

14 d

Dose descriptor:

NOEC

Effect conc.:

100 mg/L

Nominal / measured:

nominal

Conc. based on:

other: read-across approach from analogue alpha terpineol

Basis for effect:

other: read-across approach from analogue alpha terpineol for which a ready biodegradability test was conducted up tp 100 mg/L.

Remarks on result:

other: read-across approach from analogue alpha terpineol determined to be ready biodegradable

Details on results:

Based on the experimental results on analogue substance alpha terpineol where NOEC was determined to be 100 mg/L based on biodegradation of 84.6% at 14 days, the read-across approach was applied and NOEC for L-alpha terpineol was calculated to be 100 mg/L.

Validity criteria fulfilled:

not applicable

Conclusions:

Based on the experimental results from a biodegradation test performed on analogue substance alpha terpineol, the NOEC (14d) for microorganism toxicity of laevo alpha terpineol was determined to be 100 mg/L.

Executive summary:

A ready biodegradability test was perfomed on alpha terpineol. The test item was incubated for 14 days at a concentration of 100 mg/L with 30 mg/L SS activated sludge inoculum under aerobic conditions in a mineral medium. The NOEC (14d) of the test item was determined to be 100 mg/L since the substance degraded well (84.6% of biodegradation at 14 days). Based on these results, the read-across approach was applied and 14 day-NOEC for L-alpha terpineol was calculated to be 100 mg/L.

Description of key information

Key study. Read-across approach. Test method according to OECD 301C. Based on the experimental results on analogue substance alpha terpineol, the read-across approach was applied and 14 day-NOEC for laevo alpha terpineol was determned to be 100 mg/L.

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:

100 mg/L

Additional information

Key study. Read-across approach. A ready biodegradability test was perfomed on the analogue substance alpha terpineol according to OECD Guideline 301C. Under the test conditions, the NOEC (14d) of the analogue was determined to be 100 mg/L since the substance degraded well (84.6% of biodegradation at 14 days). Based on these results, the read-across approach was applied and 14 day-NOEC for laevo alpha terpineol was calculated to be 100 mg/L.