Myo-Inositol, hexakis(dihydrogen phosphate), dodecasodium salt

Density

Link to relevant study record(s)

Reference

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23. Oct. 2017 - 26. Oct. 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study was performed in accordance with GLP requirements and no deviations were ascertained.

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Version / remarks:

OECD Guidelines for the Testing of Chemicals, Method No. 109, adopted 02. Oct. 2012: “Density of Liquids and Solids “

Deviations:

not specified

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Version / remarks:

Council Regulation (EC) No 440/2008 from 30 May 2008, published on 31. May 2008, Method A.3: “Relative Density”

Deviations:

not specified

GLP compliance:

yes (incl. QA statement)

Type of method:

pycnometer method

Key result

Type:

density

Density:

>= 1.817 - <= 1.819 g/cm³

Temp.:

20 °C

Remarks on result:

other: n=2 measurements, Standard deviation is: 0.0021 g/cm³

Key result

Type:

relative density

Density:

>= 1.817 - <= 1.819 other: no unit

Temp.:

20 °C

Remarks on result:

other:

Remarks:

The relative density of the test item has the same number value, but no unit.

Results of the single determinations with the respective error as well as the mean value and its standard deviation are presented in the following tables:

Table: Results of Single Determinations

Determination	Density in g/cm^3	Error of Determ. in g/cm^3
1	1.8163	0.0008
2	1.8193	0.0008

 Table: Results – Mean Values

Parameter	Value	Unit	Standard Deviation	Relative Standard Deviation
Volume of Pycnometer	50.46	cm^3	0.0026	0.01%
Density of Test Item	1.8178	g/cm^3	0.0021	0.12%
Density of Test Item	1817.8	kg/m^3	2.1	0.12%
Relative Density of Test Item	1.8178		0.0021	0.12%

 

Conclusions:

Density was calculated as 1.8178 ± 0.0008 g/cm³ at 20.0 ± 0.2°C.

Executive summary:

The density of the test item determined by pycnometer method was calculated as 1.8178 ± 0.0008 g/cm³ at 20.0 ± 0.2°C, which is the mean of two values. Precision of the value is given as maximal error of a single determination. Standard deviation was 0.0021 g/cm³, showing good correlation of the two determinations. Therefore, the study is considered valid.

The relative density of the test item has the same number value, but no unit, assuming that relative density is given as the ratio of test item density to density of water at 4°C, having a standard density of 0.999975

g/cm³ (source: CRC Handbook of Chemistry and Pyhsics - 90th edition / Section 6 - Fluid properties - p.6 -7).

Description of key information

Density: 1.8178 +/- 0.0008 g/cm³ at 20°C +/- 0.2°C (Method OECD 109;  respectively to EEC Guideline EU A.3; pycnometer method).

The relative density of the test item has the same number value, but no unit.

Key value for chemical safety assessment

Relative density at 20C:

1.818

Additional information

The density of the test item determined by pycnometer method was calculated as 1.8178 ± 0.0008 g/cm³ at 20.0 ± 0.2°C, which is the mean of two values. Precision of the value is given as maximal error of a single determination. Standard deviation was 0.0021 g/cm³, showing good correlation of the two determinations. Therefore, the study is considered valid.

The relative density of the test item has the same number value, but no unit, assuming that relative density is given as the ratio of test item density to density of water at 4°C, having a standard density of 0.999975

g/cm³ (source: CRC Handbook of Chemistry and Pyhsics - 90th edition / Section 6 - Fluid properties - p.6 -7).