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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study obtained through inquiry process; SNIF file obtained from ECHA.

Data source

Reference
Reference Type:
other: SNIF
Title:
Unnamed
Year:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
Body responsible for the test
IUPAC Name:
Body responsible for the test

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
not specified
Amount / concentration applied:
Amount applied: 100 mg
Duration of treatment / exposure:
24 h
Number of animals or in vitro replicates:
1

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Remarks:
(redness)
Basis:
animal #1
Remarks:
(mean score 1)
Time point:
other: 24 h
Score:
2
Max. score:
2
Reversibility:
other: test terminated before reversibility could be determined.
Irritation parameter:
chemosis score
Basis:
animal #1
Remarks:
(mean score 1)
Time point:
other: 24 h
Score:
4
Max. score:
4
Reversibility:
other: test terminated before reversibility could be determined.
Irritation parameter:
cornea opacity score
Basis:
animal #1
Remarks:
(mean score 1)
Time point:
other: 24 h
Score:
0
Max. score:
0
Reversibility:
other: test terminated before reversibility could be determined.
Irritation parameter:
iris score
Basis:
animal #1
Remarks:
(mean score 1)
Time point:
other: 24 h
Score:
1
Max. score:
1
Reversibility:
other: test terminated before reversibility could be determined.
Other effects:
No further toxicological observations.

Any other information on results incl. tables

Due to the severeness of the damages the test was cancelled after 24 h for reasons of animal protection.

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye)
Remarks:
Migrated information Criteria used for interpretation of results: other: EU-GHS
Conclusions:
The substance is severely irritating to the eyes of rabbits.
Executive summary:

The test substance was tested to be severly irritating to the eyes of rabbits ( 1 animals) in a GLP study according to OECD Guideline No. 405. Due to the severeness of the damages the test was cancelled after 24 h for reasons of animal protection.