Registration Dossier
Registration Dossier
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EC number: 278-674-2 | CAS number: 77365-64-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 30, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- 1995
- GLP compliance:
- not specified
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- photometric method
- Type:
- Pow
- Partition coefficient:
- ca. 0.015
- Temp.:
- 20 °C
- pH:
- ca. 4.62
- Type:
- log Pow
- Partition coefficient:
- ca. -1.926
- Temp.:
- 20 °C
- pH:
- ca. 4.62
- Details on results:
- A first scan of the solutions was performed in the range 190 – 800 nm to choose the best wavelength peak for the quantitative measurements. In the case of test item: λ= 542.5 nm. Concentration of the n-octanol phase was very low: even applying direct measurement of the n-octanol phase, there was no evidence of migration.
- Conclusions:
- The average Pow measured is 0.01482 at pH of 4.62, the average log Pow measured is - 1.9256
- Executive summary:
Method
Partition coefficient was determined by OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method).
n- octanol and double distilled water were pre saturated: enough quantity of double distilled water was mixed with n-octanol at room temperature and kept under agitation during 24 hours, then allowing phase separation. Analogous procedure was followed for n-octanol with addition of double distilled water.
Approximately exactly 0.1 g test sample was weighed and dissolved with double distilled water saturated in n-octanol to 250 ml in a volumetric flask (mother solution). pH was recorded.
Results
The average Pow measured is 0.01482 at pH of 4.62, the average log Pow measured is - 1.9256 at 20 °C.
Reference
Description of key information
logPow = -1.9256, at 20 °C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.926
- at the temperature of:
- 20 °C
Additional information
Partition coefficient was determined by OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method), adopted 27.05.95.
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