Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 616-328-8 | CAS number: 76359-37-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Analogue substance tested.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- Analogue substance (refer to IUCLID chapter 13)
- IUPAC Name:
- Analogue substance (refer to IUCLID chapter 13)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 2 % solution of CMC in distilled water
- Doses:
- Application Volume/kg body weight:
Group 1: 10 ml at 1000 mg/kg
Group 2: 20 ml at 5000 mg/kg
Group 3: 20 ml at 8000 mg/kg - No. of animals per sex per dose:
- Number of animals per group/per dose: 5 males, 5 females
Total number of animals: 15 males, 15 females - Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 028 mg/kg bw
- Clinical signs:
- other: The following symptoms were observed: 1000 mg/kg: dyspnea 5000 mg/kg: sedation, dyspnea, ataxia, curved body position, ruffled fur, extremities bluish discolored 8000 mg/kg: sedation, dyspnea, ataxia, ventral body position, latero-abdominal body position,
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- The acute oral toxicity test was carried out with the analogue substance. Based on the results of the test, the LD50 of the analogue substance in rats of both sexes observed for a period of 15 days is 4028 mg/kg. Due to the structural similarity of the analogue substance and the substance subject of registration it can be derived that LD50 for the substance subject to registration will be > 2000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
