Registration Dossier
Registration Dossier
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EC number: 227-022-5 | CAS number: 5601-29-6
Endpoint summary
Administrative data
Description of key information
Acute toxicity, oral: LD50 = 8290 mg/kg bw
Acute toxicity, dermal: LD50 > 5000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 8 290 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Only a short abstract for the study is available. Klimish score = 4 (not assignable)
Additional information
Justification for classification or non-classification
According to the CLP Regulation (EC n. 1272/2008), 3.1 Acute toxicity section, substances can be allocated to one of four toxicity categories based on acute toxicity by the oral, dermal or inhalation route according to numeric criteria. Acute toxicity values are expressed as (approximate) LD50 (oral, dermal) or LC50 (inhalation) values or as acute toxicity estimates (ATE).
The oral LD50 value was established to be = 8290 mg/kg body weight for a Similar Substance and > 15000 mg/kg bw for the substance in itself, therefore the test substance is out of any classification limit for acute oral toxicity (oral acute toxicity Category 4: 300 < ATE ≤ 2000 mg/kg bw).
The dermal LD50 value was established to be higher than 5000 mg/kg body weight, which exceeded the highest CLP limit for classification (dermal acute toxicity Category 4: 1000 < ATE ≤ 2000 mg/kg bw).
In conclusion, the test substance is not classified for oral and dermal acute toxicity, according to the CLP Regulation (EC n. 1272/2008).
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