Registration Dossier
Registration Dossier
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EC number: 223-098-9 | CAS number: 3734-67-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Disodium 8-acetamido-1-hydroxy-2-phenylazo-naphtalene-3,6-disulphonate (Synonym: Red 2G) is known to be metabolized in male and female rats which were administered the chemical by gavage and excreted out of the living system through the urine and a minor amount in feaces. Urinary excretion of the aniline moiety takes place mainly in the form of aminophenols (in total 42-56% of the dose). Faecal excretion of these products was also observed although to a lesser degree than in urine. Thus, considering the quick time (48 hours) in which more than half of the administered dose of the chemical is excreted out of the body of rats, bio-accumulation potential is expected to be low.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
After administration of 250 mg/kg bw Red 2G to rats by gastric intubation, male and female urinary excretion was on average 61.8% and 71.5% of the dose. In 48 hours in males and females 42.2% and 56.4% of the dose was excreted as p-aminophenol. In 24 hours in males and females 9.2% and 2% of the dose was excreted as aniline, and 3% and 2.6% of the dose was excreted as unreduced dye.Thus, considering the quick time in which more than half of the administered dose of the chemical is excreted out of the body of rats, bio-accumulation potential is expected to be low.
However, the EFSA panel concluded that it would be prudent to regard Red 2G as being of safety concern since it is extensively metabolized to aniline.
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