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Diss Factsheets
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EC number: 228-601-5 | CAS number: 6303-21-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
pH
Administrative data
- Endpoint:
- pH
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Guideline:
- other: supplement of guideline 404 and 405
- Deviations:
- no
- Principles of method if other than guideline:
- 10 g of the test substance (liquid or solid) is added to 100 mL of distilled water in a 250 mL beaker. The solution or suspension is maintained for 4 hours with agitation at 37°C. Then the pH is directly measured in the solution or the aqueous phase of suspensions (after decantation or centrifugation). The sample is then titrated with diluted sodium hydroxide or hydrochloric acid until neutrality is obtained. A preliminary titration was performed for a preliminary test to allows good conditions for the alkaline reserve (R) determination: 10 mL volume of a 100 g/L solution are neutralised by approximately 95 mL of 0,1 N NaOH.
Then for a definitive test, the titration was performed three times more in the same conditions.
The acidic or alkaline reserve (R) is expressed as the number of grams of pure acid or base necessary to neutralise 100 g of product (%). - GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Phosphinic acid
- EC Number:
- 228-601-5
- EC Name:
- Phosphinic acid
- Cas Number:
- 6303-21-5
- Molecular formula:
- H3O2P
- IUPAC Name:
- phosphinic acid
- Test material form:
- other: aqueous solution
- Details on test material:
- Sample designation:
- Name of test material: phosphinic acid
- Physical state: clear liquid
- Date of reception in the test facility: 2009.12.23
Constituent 1
Results and discussion
pH value
- pH value:
- 0.71
- Temp.:
- 37 °C
- Concentration:
- 100 g/L
Any other information on results incl. tables
Under the test conditions, the aqueous phosphinic acid shows an acidic character demonstrated by a pH of 0,71 for a 100 g/L solution in water, an alkaline reserve of 38,015 (i.e log R = 1,580) and a physicochemical index of 14,870.
Table 1 : Results of neutralization experiments
|
Applicant's summary and conclusion
- Conclusions:
- Under the test conditions, the aqueous phosphinic acid shows an acidic character demonstrated by a pH of 0.71 for a 100 g/L solution in water, an alkaline reserve of 38,015 (i.e log R = 1,580) and a physicochemical index of 14,870.
- Executive summary:
The pH and Alkaline reserve of the test item phosphinic acid was measured according to the method described in the two following references JF.Regnier and C.Imbert (1992), and V.Froment (1993).
This method can be used at first step of stepwise strategy for assessing cutaneous and ocular irritation.
An amount of the test substance is added to distilled water in a beaker. The solution or suspension is maintained for 4 hours with agitation at 37° C. The pH is directly measured and the sample is then titrated with diluted sodium hydroxyde or hydrochloric acid until neutrality is obtained. The acidic or alkaline reserve (R) is expressed as the number of grams of pure acid or base necessary to neutralise 100 g of product (%).
A preliminary titration was performed for a preliminary test to allows good conditions for the alkaline reserve (R) determination: 10 mL volume of a 100 g/L solution are neutralised by approximately 95 mL of 0.1 N NaOH. Then for a definitive test, the titration were performed three times more in the same conditions.
Under the test conditions, the aqueous phosphinic acid shows an acidic character demonstrated by a pH of 0,71 for a 100 g/L solution in water, an alkaline reserve of 38,015 (i.e log R = 1,580) and a physicochemical index of 14,870.
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