Registration Dossier
Registration Dossier
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EC number: 203-896-3 | CAS number: 111-69-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via inhalation route
- Dose descriptor:
- NOAEC
- 99 mg/m³
Additional information
There were no significant detectable male/female fertility effects at any of the exposure levels tested as judged by mating efficiency, pregnancy rates, number of live implants or pre- or postimplantation loss. The fertility NOAEC was the highest concentration tested, 104 mg/m3 air. There was a slightly statistically significant reduction in mean body weights of the females during exposure weeks 2 and 3. Because this effect was observed prior to mating, the exposure concentration of 104 mg/m3 could be considered a maternal systemic LOAEC with no relation to fertility effects.
Short description of key information:
There were no significant detectable male/female fertility effects at any of the exposure levels tested as judged by mating efficiency, pregnancy rates, number of live implants or pre- or postimplantation loss. The fertility NOAEC was the highest concentration tested, 104 mg/m3 air. There was a slightly statistically significant reduction in mean body weights of the females during exposure weeks 2 and 3. Because this effect was observed prior to mating, the exposure concentration of 104 mg/m3 could be considered a maternal systemic LOAEC with no relation to fertility effects.
Effects on developmental toxicity
Description of key information
Treatment with adiponitrile did not produce a teratogenic response in OECD 414 study.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 80 mg/kg bw/day
Additional information
Treatment with adiponitrile did not produce a teratogenic response when administered orally to pregnant Charles River COBS CD rats at a dosage level of 80 mg/kg/day or less. No teratogenic response was noted in pilot study.
Justification for classification or non-classification
No reproductive effects were noted for adiponitrile.
Additional information
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