Registration Dossier
Registration Dossier
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EC number: 412-060-9 | CAS number: 136210-32-7 DESMOPHEN VP-LS 2973 E; DESMOPHEN VP-LS 2975 E; DESMOPHEN VP-LS 2985 E
Endpoint summary
Administrative data
Description of key information
Additional information
The acute toxicity of aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester towards fish (Brachydanio rerio) was determined according to the OECD-Guideline 203 yielding a LC0(96 h) ≥ 5 mg/L as no adverse effects were observed at testing concentrations up to the water solubility limit of the test item (Bayer AG, 1998b).
Aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester was tested with respect to the acute toxicity towards invertebrates (Daphnia magna) according to a national standard method: "Determination of the immobilization at daphnia", UBA, May 1984 yielding an EC50(48 h) ≥ 5 mg/L as no adverse effects were observed for testing concentrations up to the water solubility limit of the test item (Bayer AG, 1998c).
The chronic toxicity of aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester towards reproduction of Daphnia magna was tested according to the EC-method C.20, No. 440/2008 yielding the following results (Currenta, 2009d):
21d-NOEC (reproduction): 0.013 mg/L
21d-LOEC (reproduction): 0.041 mg/L
21d-NOEC (mortality): >= 0.12 mg/L
21d-LOEC (mortality): > 0.12 mg/L
Aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester was tested for toxicity towards algal growth according to the OECD-Guideline 201 yielding an ErC 50 (0 - 48 h) > 1.319 mg/L as no toxic effects were observed at testing concentrations up to the water solubility limit of the test item (Currenta, 2010b).
The effect of aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester towards the growth of activated sludge was investigated according to ISO 8192 -1986 (E) having an EC50(3 h) of 3110 mg/L (Bayer AG, 1998d). Therefore, an adverse effect towards microorganisms and thus the cleaning capacity of sewage treatment plants is not expected.
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