Bis(2-methylisouronium) sulphate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March 1991

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1991

Report date:

1991

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Bis(2-methylisouronium) sulphate

EC Number:

257-851-8

EC Name:

Bis(2-methylisouronium) sulphate

Cas Number:

52328-05-9

Molecular formula:

C4H14N4O6S

IUPAC Name:

O-methyl-isourea sulphate

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: mist

Type of inhalation exposure:

head only

Vehicle:

air

Analytical verification of test atmosphere concentrations:

yes

Duration of exposure:

ca. 4 h

Concentrations:

2.13 mg/l

No. of animals per sex per dose:

five

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LC0

Effect level:

> 2.133 mg/L air (analytical)

Based on:

test mat.

Exp. duration:

4 h

Effect levels 2

Key result

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 2.133 mg/L air (analytical)

Based on:

test mat.

Exp. duration:

4 h

Mortality:

none

Any other information on results incl. tables

Exposure to O-Methylisourea sulfate techical at a single chamber concentration of 2.133 mg/L did not cause mortality. Minor signs of toxicity such as changes in clinical condition and a small reduction in body weight gain were considered not to be significant signs of toxicity.

Using standard toxicity assessment criteria the test article can be classified as non-toxic or slightly toxic. As the maximum practical concentration used produced only slight signs of toxicity the test article is of low acute toxicity and should probably be classified as non-toxic.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Remarks:

Migrated information

Conclusions:

At a concentration of 2.133 mg/L no death occured.

Executive summary:

Exposure to O-Methylisourea sulfate techical at a single chamber concentration of 2.133 mg/L did not cause mortality. Minor signs of toxicity such as changes in clinical condition and a small reduction in body weight gain were considered not to be significant signs of toxicity.

Using standard toxicity assessment criteria the test article can be classified as non-toxic or slightly toxic. As the maximum practical concentration used produced only slight signs of toxicity the test article is of low acute toxicity and should probably be classified as non-toxic.